Featured Research

from universities, journals, and other organizations

Gene Vaccine For Alzheimer's Disease Shows Promising Results

Date:
January 4, 2005
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
UT Southwestern Medical Center at Dallas researchers have found a way of stimulating the immune systems of mice to fight against amyloid proteins that cause the devastating plaques that are characteristic of Alzheimer's disease.

DALLAS - Dec. 13, 2004 - UT Southwestern Medical Center at Dallas researchers have found a way of stimulating the immune systems of mice to fight against amyloid proteins that cause the devastating plaques that are characteristic of Alzheimer's disease.

For years scientists have examined the possibility of using a protein-based vaccine to slow the progression of the disease in its early stages. UT Southwestern researchers have created a gene-based vaccine aimed at stimulating the immune systems of mice to potentially fight off plaque-causing amyloid protein in the brain.

Their findings appear in today's issue of the Archives of Neurology.

"Previous Alzheimer's vaccines were protein-based," said Dr. Baoxi Qu, the study's lead author and assistant professor in the Center for Biomedical Inventions and internal medicine. "We wanted to try a DNA-based genetic vaccine instead to see if we could enhance the immune response."

Although prior studies of amyloid protein vaccination had shown some slowing in the plaque buildup, negative side effects also occurred in a handful of patients. Some had autoimmune responses that caused encephalitis.

The key in the UT Southwestern study was finding another way to vaccinate patients without stimulating the body's own immune cytotoxic T cells, said Dr. Roger Rosenberg, a study author and director of the Alzheimer's Disease Center.

"This dilemma was discussed with my colleagues, and we decided to try vaccination with an amyloid gene, rather than the amyloid protein vaccine," said Dr. Rosenberg.

The UT Southwestern researchers vaccinated mice with a "gene gun." The gene gun and gene-vaccination technologies were invented by Dr. Stephen Albert Johnston, director of the Center for Biomedical Inventions and senior author of the latest study.

"We have been developing ways to use gene-immunization to manipulate the immune response," Dr. Johnston said. "This study was the first step to see if we can apply these techniques to create a safe and effective Alzheimer's vaccine." Said Dr. Rosenberg: "When we vaccinated the mice with the mouse form of the amyloid gene, they made lots of antibodies without stimulating cytotoxic T cells. When we get to human studies, we hope to show that humans can make human antibodies against the amyloid as well."

Current treatments for Alzheimer's disease focus on the symptoms since no therapies have been clinically proven to slow or prevent progression of the disease. Amyloid protein deposits are present in the early phase of the disease - a fact that suggests a gene vaccination would be a step forward in slowing the progression of dementia.

From the mouse studies and in previous clinical trials of patients with Alzheimer's disease, immunization with amyloids slowed the buildup of plaque in the brain and appeared to slow cognitive loss.

"Although human clinical trials are still at least two years out, theoretically, we are on the right track," he said.

Other UT Southwestern authors involved in the study were Dr. Liping Li, a research fellow in the Center for Biomedical Inventions; and Dr. Philip Boyer, assistant professor of pathology.

The study was supported in part by National Institute on Aging and the Rudman Foundation.


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "Gene Vaccine For Alzheimer's Disease Shows Promising Results." ScienceDaily. ScienceDaily, 4 January 2005. <www.sciencedaily.com/releases/2004/12/041219192728.htm>.
University Of Texas Southwestern Medical Center At Dallas. (2005, January 4). Gene Vaccine For Alzheimer's Disease Shows Promising Results. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2004/12/041219192728.htm
University Of Texas Southwestern Medical Center At Dallas. "Gene Vaccine For Alzheimer's Disease Shows Promising Results." ScienceDaily. www.sciencedaily.com/releases/2004/12/041219192728.htm (accessed July 25, 2014).

Share This




More Mind & Brain News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

University Quiz Implies Atheists Are Smarter Than Christians

University Quiz Implies Atheists Are Smarter Than Christians

Newsy (July 25, 2014) An online quiz from a required course at Ohio State is making waves for suggesting atheists are inherently smarter than Christians. Video provided by Newsy
Powered by NewsLook.com
Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Can Watching TV Make You Feel Like A Failure?

Can Watching TV Make You Feel Like A Failure?

Newsy (July 24, 2014) A study by German researchers claims watching TV while you're stressed out can make you feel guilty and like a failure. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins