Featured Research

from universities, journals, and other organizations

Study Provides Clues To Alcohol's Cancer Connection

Date:
December 29, 2004
Source:
John Wiley & Sons, Inc.
Summary:
For the first time scientists have demonstrated a model that may explain how alcohol stimulates tumor growth. Their study, published in the January 15, 2005 issue of CANCER, says alcohol fuels the production of a growth factor that stimulates blood vessel development in tumors, and that chronic ethanol increased tumor size and levels of the angiogenic factor and levels of the angiogenic factor and vascular endothelial growth factor (VEGF) in an experimental model.

For the first time scientists have demonstrated a model that may explain how alcohol stimulates tumor growth. Their study, published in the January 15, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), says alcohol fuels the production of a growth factor that stimulates blood vessel development in tumors, and that chronic ethanol increased tumor size and levels of the angiogenic factor and levels of the angiogenic factor and vascular endothelial growth factor (VEGF) in an experimental model.

For almost a hundred years mounting epidemiological evidence has linked alcohol use to an increased risk of cancers of the stomach, esophagus, liver, breast, and colon. Researchers have never developed an adequate model to explain how ethanol or a metabolite of ethanol may cause cancer. Hypotheses abound, and include such diverse theories as acetaldehyde carcinogenicity, dietary imbalances, and impaired nutrient metabolism and detoxification due to alcohol consumption, activation of precancerous enzymes, and suppression of the immune system.

Recent data in a cellular model has demonstrated that ethanol increases cellular production of VEGF, an important signaling protein in blood vessel growth, particularly in tumors. Jian-Wei Gu. M.D. from the University of Mississippi Medical Center and colleagues further investigated the possible mechanism between ethanol-induced blood vessel growth and VEGF using a chick embryo model. The investigators exposed chick embryos inoculated with fibrosarcoma cells to saline or physiologically relevant levels of ethanol for nine days.

The investigators found that compared to the saline control group, the embryos exposed to ethanol experienced increases in tumor size, tumor blood vessel density, cancer cell infiltration of blood vessels, and VEGF levels. Tumor volume and intratumoral vascular volume more than doubled. There was also a significant dose-related increase in VEGF mRNA and protein expression in tumors and cultured cells. Embryos exposed to ethanol had more than eight times the level of cancer cell invasion of blood vessels compared to the control group.

The authors say their findings "support the hypothesis that the induction of angiogenesis and VEGF expression by ethanol represent an important mechanism of cancer progression associated with alcoholic beverage consumption."

###

Article: "Ethanol Stimulates Tumor Progression and Expression of Vascular Endothelial Growth Factor in Chick Embryos,"Jian-Wei Gu, Amelia Purser Bailey, Amanda Sartin, Ian Makey, Ann L. Brady, CANCER; Published Online: December 13, 2004 (DOI: 10.1002/cncr.20781); Print Issue Date: January 15, 2005.


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Study Provides Clues To Alcohol's Cancer Connection." ScienceDaily. ScienceDaily, 29 December 2004. <www.sciencedaily.com/releases/2004/12/041220023731.htm>.
John Wiley & Sons, Inc.. (2004, December 29). Study Provides Clues To Alcohol's Cancer Connection. ScienceDaily. Retrieved October 23, 2014 from www.sciencedaily.com/releases/2004/12/041220023731.htm
John Wiley & Sons, Inc.. "Study Provides Clues To Alcohol's Cancer Connection." ScienceDaily. www.sciencedaily.com/releases/2004/12/041220023731.htm (accessed October 23, 2014).

Share This



More Health & Medicine News

Thursday, October 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com
U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

U.S. Issues Ebola Travel Restrictions, Are Visa Bans Next?

Newsy (Oct. 22, 2014) Now that the U.S. is restricting travel from West Africa, some are dropping questions about a travel ban and instead asking about visa bans. Video provided by Newsy
Powered by NewsLook.com
US to Track Everyone Coming from Ebola Nations

US to Track Everyone Coming from Ebola Nations

AP (Oct. 22, 2014) Stepping up their vigilance against Ebola, federal authorities said Wednesday that everyone traveling into the US from Ebola-stricken nations will be monitored for symptoms for 21 days. (Oct. 22) Video provided by AP
Powered by NewsLook.com
Doctors Help Paralysed Man Walk Again, Patient in Disbelief

Doctors Help Paralysed Man Walk Again, Patient in Disbelief

AFP (Oct. 22, 2014) Polish doctors describe how they helped a paralysed man walk again, with the patient in disbelief at the return of sensation to his legs. Duration: 1:04 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins