Featured Research

from universities, journals, and other organizations

Old T Cells Cripple Immune Function In The Elderly

Date:
December 21, 2004
Source:
Journal Of Experimental Medicine
Summary:
T cells are the weakest link in the immune systems of older people, based on a report by Eaton and colleagues in the December 20 issue of The Journal of Experimental Medicine. The authors show that old CD4 "helper" T cells cannot provide the stimulatory signals to B cells that prompt them to make antibodies. Old and young B cells, however, are equally effective if helped by young CD4 T cells. The authors think this may help explain why immunizations are less effective in the elderly.

T cells are the weakest link in the immune systems of older people, based on a report by Eaton and colleagues in the December 20 issue of The Journal of Experimental Medicine. The authors show that old CD4 "helper" T cells cannot provide the stimulatory signals to B cells that prompt them to make antibodies. Old and young B cells, however, are equally effective if helped by young CD4 T cells. The authors think this may help explain why immunizations are less effective in the elderly.

B cell activation and antibody production are known to be impaired with age in both mice and humans, but it was not clear whether this defect is intrinsic to B cells or is a by-product of declining CD4 T cell helper functions.

Eaton and colleagues transferred young or old CD4 T cells into mice lacking their own CD4 T cells to determine which cells are responsible for the age-related decline in B cell function. They show that B cell activation and antibody production can be restored in old mice if they are infused with young CD4 T cells prior to immunization. On the flip side, young mice infused with old CD4 T cells developed antibody defects, even though their B cells were young. In other words, old B cells function like young ones if provided with signals from young helper T cells. While the mechanism is not completely clear, the authors show that old T cells can travel to the right location in the spleen of the mice, but have fewer of the surface proteins that send stimulatory signals to B cells.


Story Source:

The above story is based on materials provided by Journal Of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of Experimental Medicine. "Old T Cells Cripple Immune Function In The Elderly." ScienceDaily. ScienceDaily, 21 December 2004. <www.sciencedaily.com/releases/2004/12/041220121651.htm>.
Journal Of Experimental Medicine. (2004, December 21). Old T Cells Cripple Immune Function In The Elderly. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2004/12/041220121651.htm
Journal Of Experimental Medicine. "Old T Cells Cripple Immune Function In The Elderly." ScienceDaily. www.sciencedaily.com/releases/2004/12/041220121651.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins