Featured Research

from universities, journals, and other organizations

New Test Possible Aid To Overcoming Barriers To Colon Cancer Screening

Date:
January 13, 2005
Source:
Indiana University
Summary:
A new option for non-invasive colorectal cancer testing may encourage some people who avoid screening for the deadly disease to be tested.

INDIANAPOLIS -- A new option for non-invasive colorectal cancer testing may encourage some people who avoid screening for the deadly disease to be tested.

A study published in the December 23 issue of the New England Journal of Medicine reports that a non-invasive test for DNA mutations present in stool has an encouraging rate of detecting colorectal cancer compared to the standard non-invasive method -- fecal occult (hidden) blood stool testing, although neither approached the detection rate of colonoscopy, an invasive procedure.

"A simple, non-invasive test that detects tumor-specific products with reasonable sensitivity and specificity might overcome barriers to screening among persons who are not willing to have a more invasive test, such as colonoscopy," said Thomas Imperiale, M.D., professor of medicine at the Indiana University School of Medicine and a research scientist at the Regenstrief Institute.

The study, conducted at 81 sites by Dr. Imperiale and colleagues of the Colorectal Cancer Study Group, reports that in average risk, asymptomatic individuals the fecal occult blood test -- which tests blood hidden in stool -- found only 13 percent of colorectal cancer; while the new stool DNA test detected 52 percent of the cancers. Colonoscopy, which is presumed to find all colon cancers, is the "gold standard" against which all other tests are measured.

Typically, colorectal cancer develops slowly over a period of several years, usually beginning as a growth of tissue known as a polyp that develops on the lining of the colon or rectum. Most cancerous lesions bleed intermittently, however many precancerous polyps do not bleed. Absence of fecal occult blood cannot rule out cancer or precancerous lesions.

Previous studies have found that polyps as well as cancerous lesions may shed abnormal DNA. It is this DNA which the stool DNA panel analyzes. Although researchers found that the majority of precancerous polyps discovered during colonoscopy were not detected by either non-invasive test, they report that the stool DNA panel detected a greater proportion than did analysis of stool blood.

Despite national guidelines recommending screening, fewer than half of American adults aged 50 years and older have had a recent examination for colorectal cancer at the proper interval according to Centers for Disease Control.

"There are many reasons why people don't get screened for colon cancer," said Dr. Imperiale. "Some individuals do not want colonoscopy because of discomfort despite conscious sedation, its inconvenience, or its risk for complications; others are unwilling to smear stool samples on a card for the occult blood test every year." The stool DNA panel test, which requires a single sample expelled from the body directly into a container, gives people who are not getting screened with any of the currently available methods, another noninvasive option.

According to the American Cancer Society colon cancer is the third leading cause of cancer death among men and women in the United States.

###

The study was funded by grants from EXACT Sciences, Inc., manufacturer of the stool DNA panel.


Story Source:

The above story is based on materials provided by Indiana University. Note: Materials may be edited for content and length.


Cite This Page:

Indiana University. "New Test Possible Aid To Overcoming Barriers To Colon Cancer Screening." ScienceDaily. ScienceDaily, 13 January 2005. <www.sciencedaily.com/releases/2005/01/050111180754.htm>.
Indiana University. (2005, January 13). New Test Possible Aid To Overcoming Barriers To Colon Cancer Screening. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2005/01/050111180754.htm
Indiana University. "New Test Possible Aid To Overcoming Barriers To Colon Cancer Screening." ScienceDaily. www.sciencedaily.com/releases/2005/01/050111180754.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins