Featured Research

from universities, journals, and other organizations

New Non-Hormonal Hot Flash Treatment Set For Clinical Trial

Date:
February 7, 2005
Source:
University At Buffalo
Summary:
A novel non-estrogen-based therapy for hot flashes will be tested for effectiveness in a clinical trial conducted by researchers at the University at Buffalo that is set to begin in February.

BUFFALO, N.Y. -- A novel non-estrogen-based therapy for hot flashes will be tested for effectiveness in a clinical trial conducted by researchers at the University at Buffalo that is set to begin in February.

Related Articles


The trial will assess the effectiveness of an amino acid, an all-natural, non-hormonal dietary supplement, to eliminate the sudden flushes that plague many postmenopausal women.

The study is funded by a $665,550 grant from the National Center for Complimentary and Alternative Medicine of the National Institutes of Health.

Amino acids are the molecules that combine to make proteins, the body's building blocks. Many amino acids are acquired through the diet. The UB researchers theorize that doses higher than can be achieved in a normal diet of certain amino acids will reduce hot flash activity.

Amino acid therapy appears to act on the hypothalamus, the part of the brain that regulates temperature.

Thomas Guttuso, Jr., M.D., UB assistant professor of neurology and principal investigator on the clinical trial, conducted a small study in 2004 using the amino acid treatment with 15 postmenopausal women.

"The study showed very promising results in decreasing hot flashes among these women, indicating the treatment deserved further investigation," Guttuso related. He now is preparing to conduct a 12-week study involving 100 women with hot flashes.

Half the women will get the active treatment in capsule form, and half will receive an inactive capsule. Participants will report the number of hot flashes a day and their intensity in a diary throughout the trial to determine the treatment's effectiveness.

Guttuso discovered the potential of amino acid treatment for hot flashes accidentally while treating a patient for migraine headaches.

"I placed a woman who was complaining of migraines on an amino-acid-based prescription treatment called gabapentin that has been shown to help prevent migraine headaches. A week later she called to tell me her hot flashes were gone.

"This certainly was an unexpected effect of the medication," he said. "It made me start to think that perhaps some of the all-natural amino acids may also be effective hot flash therapies."

The gold standard hot-flash therapy for years has been hormone replacement therapy, or HRT, but more information has come to light showing that HRT might have some dangerous side effects.

"Since there were not many non-hormonal hot flash therapies available, and because the number of women with hot flashes is so large -- about 30 million women in the U.S. -- the University of Rochester, where I was working at the time, patented the discovery."

Guttuso, meanwhile, published the first paper on this new use of an amino acid in the journal Neurology in 2000. He followed that with a paper in Obstetrics & Gynecology in 2003 reporting on the successful use of gabapentin for hot flashes in a randomized clinical trial involving 59 women.

The amino acid to be tested in the upcoming trial, while not gabapentin, is known to work through the same mechanism.

Guttuso will begin recruiting women for the study in February. Potential participants may call 716-829-2482 for more information.


Story Source:

The above story is based on materials provided by University At Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University At Buffalo. "New Non-Hormonal Hot Flash Treatment Set For Clinical Trial." ScienceDaily. ScienceDaily, 7 February 2005. <www.sciencedaily.com/releases/2005/02/050205110008.htm>.
University At Buffalo. (2005, February 7). New Non-Hormonal Hot Flash Treatment Set For Clinical Trial. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2005/02/050205110008.htm
University At Buffalo. "New Non-Hormonal Hot Flash Treatment Set For Clinical Trial." ScienceDaily. www.sciencedaily.com/releases/2005/02/050205110008.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins