Featured Research

from universities, journals, and other organizations

Prostate Cancer Vaccine Is First To Increase Survival

Date:
March 2, 2005
Source:
University Of California, San Francisco
Summary:
For the first time, researchers have found that a novel immunologic therapy increases survival by nearly 18 percent in men with advanced prostate cancer that no longer responds to hormone therapy.

For the first time, researchers have found that a novel immunologic therapy increases survival by nearly 18 percent in men with advanced prostate cancer that no longer responds to hormone therapy.

The therapeutic cancer vaccine, called APC8015 (Provenge), is likely to become a new standard of care for patients with metastatic prostate cancer. The UCSF-led study is the first to demonstrate a survival benefit from immunologic therapies or vaccines in patients with advanced prostate cancer.

"We’re very pleased with the results. A therapy that prolongs life yet avoids the side effects of other therapeutic approaches is clearly attractive to patients and physicians alike," said Eric Small, MD, UCSF professor of medicine and urology and lead investigator of the study.

The study will be presented in Orlando, Florida, on Saturday, Feb. 19, at a prostate cancer symposium sponsored by the American Society of Clinical Oncology, the Prostate Cancer Foundation, the American Society for Therapeutic Radiology and Oncology, and the Society of Urologic Oncology.

Although the new agent is called a vaccine, it is not designed to prevent cancer. Rather, it uses the patient’s own immune system to recognize and attack existing cancer cells. APC8015 is designed to stimulate the immune system to attack cells that express prostatic acid phosphatase (PAP), a protein found on approximately 95% of prostate cancer cells.

APC8015 is produced by collecting blood from each patient, isolating the relevant immune cells, and stimulating those cells so that they recognize PAP as "foreign." The resulting product, APC8015, is administered as an intravenous infusion.

In this study, investigators randomized 127 men with asymptomatic metastatic prostate cancer that no longer responded to hormone therapy to receive the vaccine (82 men) or a placebo (45 men). Patients received three doses of the vaccine at two-week intervals, and were followed for three years.

Overall survival among patients receiving the vaccine was 25.9 months, compared to 22 months in the placebo group. Three years later, more than three times as many vaccine patients (34 percent) were still alive, compared to the placebo group (11 percent). Treatment was well-tolerated – fever and shaking were reported as the most common side effects, and generally disappeared within two days of vaccine administration.

Therapeutic vaccines are being studied in the treatment of other types of cancer including lymphoma, leukemia, and cancers of the brain, breast, lung, kidney, ovary, pancreas, colon, and rectum.

In 2004, 26,000 men in the US died of prostate cancer. Prostate cancer is the most often diagnosed non-skin cancer in the US and the third most-common cancer worldwide, according to the American Cancer Society. Of the 185,000 men diagnosed each year in the US, an estimated 10-15 percent already have metastatic disease at the time of diagnosis, and another estimated 20 percent will develop metastatic disease.


Story Source:

The above story is based on materials provided by University Of California, San Francisco. Note: Materials may be edited for content and length.


Cite This Page:

University Of California, San Francisco. "Prostate Cancer Vaccine Is First To Increase Survival." ScienceDaily. ScienceDaily, 2 March 2005. <www.sciencedaily.com/releases/2005/02/050222111915.htm>.
University Of California, San Francisco. (2005, March 2). Prostate Cancer Vaccine Is First To Increase Survival. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2005/02/050222111915.htm
University Of California, San Francisco. "Prostate Cancer Vaccine Is First To Increase Survival." ScienceDaily. www.sciencedaily.com/releases/2005/02/050222111915.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com
Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins