Featured Research

from universities, journals, and other organizations

A Possible New Phase For Rheumatoid Arthritis Treatment

Date:
April 22, 2005
Source:
BioMed Central
Summary:
New research published in Arthritis Research & Therapy found that very early rheumatoid arthritis is characterised by a distinct profile of T cell, macrophage and stromal cell related cytokines in synovial fluid.

April 7, 2005 -- The pathology of rheumatoid arthritis within the first few months after symptom onset is distinct from that of the early phases of other inflammatory joint diseases and also of established rheumatoid arthritis. New research published today in Arthritis Research & Therapy found that very early rheumatoid arthritis is characterised by a distinct profile of T cell, macrophage and stromal cell related cytokines in synovial fluid. This finding of a distinct phase of rheumatoid arthritis, immediately after the onset of clinical symptoms, provides a new rationale for the very early treatment of rheumatoid arthritis - before the disease develops into a long-term condition.

The synovium, the connective tissue membrane that lines the joints, is the primary site of pathology in rheumatoid arthritis. Although the processes that maintain long-term inflammation of the synovium in rheumatoid arthritis have been well studied, those initiating the inflammation have not, and very few groups have studied the pathology of rheumatoid arthritis within the first few weeks after the onset of symptoms.

Karim Raza and colleagues, from the University of Birmingham, U.K., investigated the processes occurring in the joints of patients within 3 months of the onset of clinical symptoms. They assessed a panel of T cell, macrophage and stromal cell related cytokines and chemokines in synovial fluid samples from inflamed joints of these patients with very early arthritis. Patients who eventually developed persistent rheumatoid arthritis had a cytokine profile that was different from that seen in patients in the early phases of other arthritic diseases, and also from that in longstanding rheumatoid arthritis - suggesting a distinct pathological process during the early phase of rheumatoid arthritis.

Rheumatoid arthritis is a common, serious and disabling autoimmune disease in which inflammation of the joint lining (or synovium) results when the body's tissues are mistakenly attacked by the immune system. Approximately eight million people are affected by rheumatoid arthritis in the UK.

Raza and colleagues speculate that the cytokines present in very early rheumatoid arthritis may be involved in the development of the microenvironment required for chronic disease. The authors propose that there is now a strong biological rationale for testing the effects of potent anti-inflammatory therapies during the first few months of clinically apparent disease. "The pathologically distinct nature of the very early phase of clinically apparent rheumatoid arthritis suggests that this phase may represent a therapeutic window," said Dr Karim Raza.

###

This press release is based on the article:

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Karim Raza, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley and Mike Salmon Arthritis Research & Therapy 2005, 7: R784-R795 (7 April 2005)


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "A Possible New Phase For Rheumatoid Arthritis Treatment." ScienceDaily. ScienceDaily, 22 April 2005. <www.sciencedaily.com/releases/2005/04/050419105542.htm>.
BioMed Central. (2005, April 22). A Possible New Phase For Rheumatoid Arthritis Treatment. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2005/04/050419105542.htm
BioMed Central. "A Possible New Phase For Rheumatoid Arthritis Treatment." ScienceDaily. www.sciencedaily.com/releases/2005/04/050419105542.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins