Featured Research

from universities, journals, and other organizations

A Possible New Phase For Rheumatoid Arthritis Treatment

Date:
April 22, 2005
Source:
BioMed Central
Summary:
New research published in Arthritis Research & Therapy found that very early rheumatoid arthritis is characterised by a distinct profile of T cell, macrophage and stromal cell related cytokines in synovial fluid.

April 7, 2005 -- The pathology of rheumatoid arthritis within the first few months after symptom onset is distinct from that of the early phases of other inflammatory joint diseases and also of established rheumatoid arthritis. New research published today in Arthritis Research & Therapy found that very early rheumatoid arthritis is characterised by a distinct profile of T cell, macrophage and stromal cell related cytokines in synovial fluid. This finding of a distinct phase of rheumatoid arthritis, immediately after the onset of clinical symptoms, provides a new rationale for the very early treatment of rheumatoid arthritis - before the disease develops into a long-term condition.

The synovium, the connective tissue membrane that lines the joints, is the primary site of pathology in rheumatoid arthritis. Although the processes that maintain long-term inflammation of the synovium in rheumatoid arthritis have been well studied, those initiating the inflammation have not, and very few groups have studied the pathology of rheumatoid arthritis within the first few weeks after the onset of symptoms.

Karim Raza and colleagues, from the University of Birmingham, U.K., investigated the processes occurring in the joints of patients within 3 months of the onset of clinical symptoms. They assessed a panel of T cell, macrophage and stromal cell related cytokines and chemokines in synovial fluid samples from inflamed joints of these patients with very early arthritis. Patients who eventually developed persistent rheumatoid arthritis had a cytokine profile that was different from that seen in patients in the early phases of other arthritic diseases, and also from that in longstanding rheumatoid arthritis - suggesting a distinct pathological process during the early phase of rheumatoid arthritis.

Rheumatoid arthritis is a common, serious and disabling autoimmune disease in which inflammation of the joint lining (or synovium) results when the body's tissues are mistakenly attacked by the immune system. Approximately eight million people are affected by rheumatoid arthritis in the UK.

Raza and colleagues speculate that the cytokines present in very early rheumatoid arthritis may be involved in the development of the microenvironment required for chronic disease. The authors propose that there is now a strong biological rationale for testing the effects of potent anti-inflammatory therapies during the first few months of clinically apparent disease. "The pathologically distinct nature of the very early phase of clinically apparent rheumatoid arthritis suggests that this phase may represent a therapeutic window," said Dr Karim Raza.

###

This press release is based on the article:

Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Karim Raza, Francesco Falciani, S John Curnow, Emma J Ross, Chi-Yeung Lee, Arne N Akbar, Janet M Lord, Caroline Gordon, Christopher D Buckley and Mike SalmonArthritis Research & Therapy 2005, 7: R784-R795 (7 April 2005)


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "A Possible New Phase For Rheumatoid Arthritis Treatment." ScienceDaily. ScienceDaily, 22 April 2005. <www.sciencedaily.com/releases/2005/04/050419105542.htm>.
BioMed Central. (2005, April 22). A Possible New Phase For Rheumatoid Arthritis Treatment. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2005/04/050419105542.htm
BioMed Central. "A Possible New Phase For Rheumatoid Arthritis Treatment." ScienceDaily. www.sciencedaily.com/releases/2005/04/050419105542.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins