Featured Research

from universities, journals, and other organizations

For Initial Treatment Of Moderate To Severe Major Depression, Cognitive Therapy And Medication May Be Equally Effective

Date:
April 20, 2005
Source:
Journal Of The American Medical Association
Summary:
Cognitive therapy, when provided by an experienced therapist, may be as effective as antidepressant medications in the initial treatment of moderate to severe major depression, according to an article in the April issue of the Archives of General Psychiatry, one of the JAMA/Archives journals.

CHICAGO — Cognitive therapy, when provided by an experienced therapist, may be as effective as antidepressant medications in the initial treatment of moderate to severe major depression, according to an article in the April issue of the Archives of General Psychiatry, one of the JAMA/Archives journals.

"Antidepressant medications are the most widely used treatment for major depressive disorder in the United States," according to background information in the article. The effectiveness of antidepressant medications has been upheld in randomized placebo-controlled trials, especially in individuals with more severe depression. Cognitive therapy has also shown potential in treating major depressive disorder.

Robert J. DeRubeis, Ph.D., from the University of Pennsylvania, Philadelphia, and colleagues compared the efficacy of antidepressant medications with cognitive therapy in 240 moderately to severely depressed patients. Study participants were randomly assigned to receive antidepressant medication (n = 120), pill placebo (n = 60), or cognitive therapy (n = 60). Those in the medication group were given paroxetine or placebo for eight weeks, with doses increasing as tolerated. After eight weeks of treatment, for those unresponsive to paroxetine, treatment was augmented with lithium carbonate or desipramine hydrochloride. Patients in the cognitive therapy group attended 50-minute sessions twice weekly for the first four weeks, once or twice weekly for the middle eight weeks, and then once weekly for the final four weeks.

At eight weeks of treatment, response rates were 50 percent in the medication group, 43 percent in the cognitive therapy group, and 25 percent in the placebo group. Of the 47 patients who received an augmented medication treatment, 32 (64 percent) were given lithium, 28 (56 percent) were prescribed desipramine, and one (two percent) was treated with venlafaxine. At sixteen weeks of treatment, response rates were 58 percent for patients receiving antidepressant medications and for those receiving cognitive therapy. Remission rates were 46 percent in antidepressant medications patients and 40 percent in cognitive therapy patients.

"On the whole, these findings do not support the current American Psychiatric Association guideline, based on the TDCRP [The Treatment of Depression Collaborative Research Program], that 'most (moderately and severely depressed) patients will require medication,' " the researchers state. "It appears that cognitive therapy can be as effective as medications, even among more severely depressed outpatients, at least when provided by experienced cognitive therapists."

(Arch Gen Psychiatry. 2005;62:409-416. Available post-embargo at archgenpsychiatry.com)

Editor's Note: This study was supported by grants from the National Institute of Mental Health, Bethesda, Md. GlaxoSmithKline, Brentford, U.K., provided medications and pill placebos for the trial.


Story Source:

The above story is based on materials provided by Journal Of The American Medical Association. Note: Materials may be edited for content and length.


Cite This Page:

Journal Of The American Medical Association. "For Initial Treatment Of Moderate To Severe Major Depression, Cognitive Therapy And Medication May Be Equally Effective." ScienceDaily. ScienceDaily, 20 April 2005. <www.sciencedaily.com/releases/2005/04/050420092142.htm>.
Journal Of The American Medical Association. (2005, April 20). For Initial Treatment Of Moderate To Severe Major Depression, Cognitive Therapy And Medication May Be Equally Effective. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2005/04/050420092142.htm
Journal Of The American Medical Association. "For Initial Treatment Of Moderate To Severe Major Depression, Cognitive Therapy And Medication May Be Equally Effective." ScienceDaily. www.sciencedaily.com/releases/2005/04/050420092142.htm (accessed August 29, 2014).

Share This




More Mind & Brain News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill 'trips' May Reduce Falls for Elderly

Treadmill 'trips' May Reduce Falls for Elderly

AP (Aug. 28, 2014) Scientists are tripping the elderly on purpose in a Chicago lab in an effort to better prevent seniors from falling and injuring themselves in real life. (Aug.28) Video provided by AP
Powered by NewsLook.com
Alice in Wonderland Syndrome

Alice in Wonderland Syndrome

Ivanhoe (Aug. 27, 2014) It’s an unusual condition with a colorful name. Kids with “Alice in Wonderland” syndrome see sudden distortions in objects they’re looking at or their own bodies appear to change size, a lot like the main character in the Lewis Carroll story. Video provided by Ivanhoe
Powered by NewsLook.com
Stopping Schizophrenia Before Birth

Stopping Schizophrenia Before Birth

Ivanhoe (Aug. 27, 2014) Scientists have long called choline a “brain booster” essential for human development. Not only does it aid in memory and learning, researchers now believe choline could help prevent mental illness. Video provided by Ivanhoe
Powered by NewsLook.com
Personalized Brain Vaccine for Glioblastoma

Personalized Brain Vaccine for Glioblastoma

Ivanhoe (Aug. 27, 2014) Glioblastoma is the most common and aggressive brain cancer in humans. Now a new treatment using the patient’s own tumor could help slow down its progression and help patients live longer. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins