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Orientation And The Egg

Date:
May 2, 2005
Source:
Cold Spring Harbor Laboratory
Summary:
In the May 1 issue of G&D, a new paper shows compelling evidence for the absence of predetermined polarity in the mouse egg. Their findings are in contrast to those who feel that the site of sperm entry determines the orientation of the future body axes.

In the May 1 issue of Genes & Development, a new paper shows compelling evidence for the absence of predetermined polarity in the mouse egg. Their findings are in contrast to those who feel that the site of sperm entry determines the orientation of the future body axes.

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The establishment of first polarity in the developing mammalian embryo is one of the most contentious topics in developmental biology today. Drs. Davor Solter and Takashi Hiiragi have new evidence to fuel the ongoing debate. Using various techniques, including comprehensive time-lapse microscopy, the researchers showed compelling evidence for the absence of predetermined polarity in the mouse egg.

Their findings are in contrast to those who feel that the site of sperm entry determines the orientation of the future body axes. "It would now make sense to base our future experiments on the premise that the mammalian egg neither has nor requires predetermination for successful development," explains Dr. Hiiragi.



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The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


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Cold Spring Harbor Laboratory. "Orientation And The Egg." ScienceDaily. ScienceDaily, 2 May 2005. <www.sciencedaily.com/releases/2005/05/050501220200.htm>.
Cold Spring Harbor Laboratory. (2005, May 2). Orientation And The Egg. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2005/05/050501220200.htm
Cold Spring Harbor Laboratory. "Orientation And The Egg." ScienceDaily. www.sciencedaily.com/releases/2005/05/050501220200.htm (accessed December 18, 2014).

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