Featured Research

from universities, journals, and other organizations

Study Shows New Method Of Growth Hormone Dosing Improves Height

Date:
June 7, 2005
Source:
University Of California - Los Angeles Health Sciences
Summary:
A randomized UCLA study found that a new dosing paradigm can improve height outcomes in the treatment of children who have short stature due to growth hormone deficiency and idiopathic short stature.

A randomized UCLA study found that a new dosing paradigm can improve height outcomes in the treatment of children who have short stature due to growth hormone deficiency and idiopathic short stature.

Related Articles


The groundbreaking study, presented at The Endocrine Society 2005 meeting in San Diego, Calif., challenges traditional approaches to growth hormone (GH) administration based upon weight.

The authors described a new dosing approach based on the serum levels of insulin-like growth factor-I (IGF-I), the growth hormone GH-dependent hormone that mediates the actions of growth hormone on the growth of children.

In the study, Dr. Pinchas Cohen, lead investigator and professor and chief of pediatric endocrinology at UCLA's Mattel Children's Hospital, along with his UCLA colleagues and collaborators from four institutions, randomized pre-pubertal children with growth hormone deficiency or short stature to one of three treatment arms: a conventional dose of growth hormone according to weight, or to one of two dosing arms where the dose was adjusted to achieve an IGF-I level that was either at the mean for age and gender, or at the upper limit of normal.

Study results showed that the change in height in children whose growth hormone dosage was increased to achieve a higher IGF-I level grew 50 percent better than children receiving fixed doses of growth hormone or whose IGF was maintained at the mean. Furthermore, the higher IGF-I arm resulted in a substantial improvement in the growth of both growth-hormone deficiency patients and patients with idiopathic short stature.

"We feel confident that IGF-based growth hormone dosing could become a novel paradigm in treating growth hormone deficiency, resulting in improved height increases for these children. The growth hormone dose targeted to achieve the higher IGF-I level produced especially meaningful increases in height compared to conventional weight-based methods of determining doses," Cohen said. "Also, the dramatic range of sensitivity to growth hormone in the study population substantiated the rationale for IGF-based dosing. This approach has important implications for both the safety and efficacy of GH."

###

This study was supported by an unrestricted grant from Novo Nordisk. Cohen is an investigator for Novo Nordisk and has received speaking honorariums from the company.


Story Source:

The above story is based on materials provided by University Of California - Los Angeles Health Sciences. Note: Materials may be edited for content and length.


Cite This Page:

University Of California - Los Angeles Health Sciences. "Study Shows New Method Of Growth Hormone Dosing Improves Height." ScienceDaily. ScienceDaily, 7 June 2005. <www.sciencedaily.com/releases/2005/06/050607005329.htm>.
University Of California - Los Angeles Health Sciences. (2005, June 7). Study Shows New Method Of Growth Hormone Dosing Improves Height. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2005/06/050607005329.htm
University Of California - Los Angeles Health Sciences. "Study Shows New Method Of Growth Hormone Dosing Improves Height." ScienceDaily. www.sciencedaily.com/releases/2005/06/050607005329.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins