Featured Research

from universities, journals, and other organizations

Test Accurately Predicts Aggressiveness Of Breast Cancer

Date:
June 8, 2005
Source:
European Society For Medical Oncology
Summary:
A test that measures how quickly cells are dividing is an accurate way for doctors to predict the aggressiveness of breast cancer tumors, even among women with very early stages of the disease, researchers told the 2nd ESMO Scientific & Educational Conference (ESEC) in Budapest, Hungary. The findings will help clinicians decide which patients will benefit most from treatment with more intensive chemotherapy.

A test that measures how quickly cells are dividing is an accurate way for doctors to predict the aggressiveness of breast cancer tumors, even among women with very early stages of the disease, researchers told the 2nd ESMO Scientific & Educational Conference (ESEC) in Budapest, Hungary. The findings will help clinicians decide which patients will benefit most from treatment with more intensive chemotherapy.

Related Articles


For most women whose invasive breast cancer is detected early, research shows that prognosis is generally excellent. But the group includes dramatically different subgroups of patients who need to be identified in order to perform the most effective treatment.

Clinicians know that the molecule Ki67 is a good indicator of cell proliferation rate, and the marker is already used to define the aggressiveness of later stages of breast cancer. But it was not clear how effective it would be in very early stages of the disease.

Dr. Monica Gionvannini and colleagues from the University of Verona in Italy analyzed 4,250 patients with early invasive breast cancer and correlated Ki67 levels with tumor size, nodal status, and other parameters.

"We found that high cell proliferation rate, measured as Ki67 levels, correlates with larger tumor size, axillary nodal involvement, higher grading, lymphovascular invasion, ER and PgR negativity, c-erbB2 overexpression, p53 mutation, younger age at diagnosis and symptomatic presentation," Dr. Giovannini said. "All these factors are well known markers of poor prognosis."

The same findings were valid also when the 'pT1' subgroup of the very earliest stage cancers was considered. "This means that very early invasive breast cancer gathers very different tumors in terms of prognosis and Ki67 could be a reliable and easily obtainable marker in order to identify which pT1 have worse prognosis," Dr. Giovannini said.

Commenting on the data, Dr. Ahmad Awada from Jules Bordet Institute, Brussels, Belgium, said the data presented by Dr. Giovannini confirm that Ki67 is a prognostic indicator in early breast cancer. "What is interesting in the analysis is that Ki67 showed the same prognostic indication in small tumors such as pT1."

"Furthermore, in clinical practice, tumors with pathological size of <1cm are a true challenge in term of therapeutic decision (mainly chemotherapy indication). Consequently, it will be important to correlate Ki67 expression and prognostic in these very small tumors (<1 cm), which ultimately could help us to use this 'easy-to-perform' parameter in the selection of therapeutic approach."

GENE LINKED TO LOWER BREAST CANCER RISK

In another presentation at the conference, Dr. Uwe Langsenlehner and colleagues from Medical University Graz in Austria showed that a specific genetic variation in a cytokine gene is associated with lower breast cancer risk.

Cytokines are molecules that act as signals between cells. The authors were examining the cytokine IL 10, which is involved in the development of various tumors.

"In breast cancer risk, IL-10 may be a two-edged sword," Dr. Langsenlehner said. "On one hand, higher IL-10 levels could facilitate development of cancer by supporting tumor escape from the immune response. On the other hand, the anti-angiogenic effects of IL-10 are supposed to prevent or reduce tumor growth and spread."

Specifically, the Austrian team examined a particular genetic arrangement, or haplotype, in the promoter region of the gene, which has been associated with increased IL-10 expression. The researchers call this the TCATA haplotype.

In a study comparing 500 women with breast cancer against 500 health controls, they found that breast cancer patients were significantly less likely to have two versions of the TCATA haplotype.

"Our study suggests that high levels of IL-10 may be protective against breast cancer," Dr. Langsenlehner said. "The mechanism for this remains to be determined, but may likely include anti-angiogenic functions of IL-10. If this result can be confirmed in additional studies, determination of IL 10 genotypes may help to obtain a more precise individual breast cancer risk profile."


Story Source:

The above story is based on materials provided by European Society For Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society For Medical Oncology. "Test Accurately Predicts Aggressiveness Of Breast Cancer." ScienceDaily. ScienceDaily, 8 June 2005. <www.sciencedaily.com/releases/2005/06/050608070707.htm>.
European Society For Medical Oncology. (2005, June 8). Test Accurately Predicts Aggressiveness Of Breast Cancer. ScienceDaily. Retrieved March 27, 2015 from www.sciencedaily.com/releases/2005/06/050608070707.htm
European Society For Medical Oncology. "Test Accurately Predicts Aggressiveness Of Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2005/06/050608070707.htm (accessed March 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com
HIV Outbreak Prompts Public Health Emergency In Indiana

HIV Outbreak Prompts Public Health Emergency In Indiana

Newsy (Mar. 26, 2015) Indiana Gov. Mike Pence says he will bring additional state resources to help stop the epidemic. Video provided by Newsy
Powered by NewsLook.com
Indiana Permits Needle Exchange as HIV Cases Skyrocket

Indiana Permits Needle Exchange as HIV Cases Skyrocket

Reuters - US Online Video (Mar. 26, 2015) Governor Mike Pence declares the recent HIV outbreak in rural Indiana a "public health emergency" and authorizes a short-term needle-exchange program. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
AAA: Distracted Driving a Serious Teen Problem

AAA: Distracted Driving a Serious Teen Problem

AP (Mar. 25, 2015) While distracted driving is not a new problem for teens, new research from the AAA Foundation for Traffic Safety says it&apos;s much more serious than previously thought. (March 25) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins