Featured Research

from universities, journals, and other organizations

Discovery May Prevent Life-threatening Wasting Disease In Patients With Chronic Kidney Disease

Date:
June 10, 2005
Source:
Oregon Health & Science University
Summary:
Researchers at Oregon Health & Science University's Doernbecher Children's Hospital have uncovered a unique therapeutic strategy to combat cachexia -- severe malnutrition and physical wasting away -- in children and adults with chronic kidney disease (CKD).

Researchers at Oregon Health & Science University's Doernbecher Children's Hospital have uncovered a unique therapeutic strategy to combat cachexia -- severe malnutrition and physical wasting away -- in children and adults with chronic kidney disease (CKD). The study is published in the June issue of the Journal of Clinical Investigation.

Although the exact cause of cachexia -- a common life-threatening complication of CKD, cancer, AIDS and heart failure patients -- is unknown, Doernbecher researchers found elevated levels of leptin, a hormone that is produced by fat cells and plays a role in weight regulation, may be the cause. Leptin signals through the hypothalamic melanocortin 4 receptor (MC4-R) pathway in the brain, and blocking this pathway may be an important avenue for treatment, they report. The study was conducted in mice.

"Understanding why patients develop cachexia is important because it is associated with very high mortality in patients with chronic kidney disease," said study investigator Robert Mak, M.D., professor of pediatrics in the OHSU School of Medicine and head of pediatric nephrology, Doernbecher Children's Hospital. "Through this research, we have found a novel therapeutic strategy to combat this life-threatening complication of chronic renal disease, which affects more than 10 percent of the population and costs $40 billion each year to treat."

In an accompanying editorial commentary, William Mitch, M.D., past president of the American Society of Nephrology and Edward Randall Distinguished Chairman in Medicine, University of Texas Medical Branch, wrote that this study "provides a quantum increase in our understanding of CKD-associated anorexia."

###

Other OHSU investigators involved in the research include: Wai Cheung, postdoctoral fellow in pediatrics, School of Medicine; Pin Xuan Yu, research assistant, Vollum Institute; Brian Little, senior research assistant in pediatrics, School of Medicine; Roger Cone, Ph.D., senior scientist in the Vollum Institute; and Daniel Marks, M.D., assistant professor of medicine (pediatric nephrology), School of Medicine.


Story Source:

The above story is based on materials provided by Oregon Health & Science University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon Health & Science University. "Discovery May Prevent Life-threatening Wasting Disease In Patients With Chronic Kidney Disease." ScienceDaily. ScienceDaily, 10 June 2005. <www.sciencedaily.com/releases/2005/06/050609233604.htm>.
Oregon Health & Science University. (2005, June 10). Discovery May Prevent Life-threatening Wasting Disease In Patients With Chronic Kidney Disease. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2005/06/050609233604.htm
Oregon Health & Science University. "Discovery May Prevent Life-threatening Wasting Disease In Patients With Chronic Kidney Disease." ScienceDaily. www.sciencedaily.com/releases/2005/06/050609233604.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins