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Stepping Up Therapy For Stroke And Other CNS Disorders

Date:
July 18, 2005
Source:
Journal of Clinical Investigation
Summary:
Stroke is a major medical problem, with only very limited treatment options. In a JCI study scientists describe new roles for G-CSF in treating stroke and other central nervous system roles of this protein. They show that G-CSF has neuron protective effects, drives neuronal differentiation of adult neural stem cells in the brain, and has profound impact on long-term functional outcome after stroke. The authors show that G-CSF can penetrate the intact blood-brain-barrier and thus be used therapeutically.

Stroke is a major medical problem, with only very limited treatment options. In a study appearing online on July 7 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Armin Schneider and colleagues from Axaron Biosciences describe new roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke and other central nervous system roles of this protein.

The team reports that G-CSF has potent cell protective effects on mature neurons, explaining why it has been shown to be useful in animal stroke models. Moreover, G-CSF drives neuronal differentiation of adult neural stem cells in the brain, and has profound impact on long-term functional outcome after cerebral ischemia. The authors show that G-CSF itself is a neuronally expressed protein in the brain, and that systemic G-CSF can penetrate the intact blood-brain-barrier.

Thus, G-CSF is a potentially novel treatment for stroke and neurodegeneration. G-CSF doubles hippocampal neurogenesis even in normal, non-ischemic animals, making it a potential drug candidate for diseases where disturbances in neurogenesis are a factor.

###

Title: The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis



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Journal of Clinical Investigation. "Stepping Up Therapy For Stroke And Other CNS Disorders." ScienceDaily. ScienceDaily, 18 July 2005. <www.sciencedaily.com/releases/2005/07/050712233843.htm>.
Journal of Clinical Investigation. (2005, July 18). Stepping Up Therapy For Stroke And Other CNS Disorders. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2005/07/050712233843.htm
Journal of Clinical Investigation. "Stepping Up Therapy For Stroke And Other CNS Disorders." ScienceDaily. www.sciencedaily.com/releases/2005/07/050712233843.htm (accessed October 2, 2014).

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