Featured Research

from universities, journals, and other organizations

PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients

Date:
August 8, 2005
Source:
Society of Nuclear Medicine
Summary:
The effectiveness of chemotherapy in patients with advanced breast cancer can be evaluated earlier by using 18F-FDG positron emission tomography (PET) imaging over other conventional imaging procedures, according to an article in the July issue of the Society of Nuclear Medicine's Journal of Nuclear Medicine.

RESTON, Va.—The effectiveness of chemotherapy in patients with advanced breast cancer can be evaluated earlier by using 18F-FDGpositron emission tomography (PET) imaging over other conventionalimaging procedures, according to an article in the July issue of theSociety of Nuclear Medicine’s Journal of Nuclear Medicine.

PET imaging performed at baseline and after the initiation oftreatment “allowed prediction of response as early as after the firstcycle of chemotherapy,” said Norbert Avril, M.D., chief of the divisionof nuclear medicine at the University of Pittsburgh Medical Center,Pittsburgh, Pa. Conventional imaging procedures, such as computedtomography (CT), magnetic resonance imaging (MRI), plain filmradiography and ultrasound, do not reliably predict therapy responseearly in the course of treatment, explained the co-author of “EarlyPrediction of Response to Chemotherapy in Metastatic Breast CancerUsing Sequential 18F-FDG PET.”

Metastatic breast cancer is the most advanced stage of breastcancer. Cancer cells have spread past the breast and underarm lymphnodes to other areas of the body, continuing to grow, multiply andpossibly spread to other regions of the body. Chemotherapy, which usesdrugs to stop the growth of cancer cells, either by killing the cellsor stopping the cells from dividing, is typically used with patients.At this advanced stage of the disease, the aim of treatment is toimprove survival and quality of life, since the disease is generallynot curable, said Avril. It’s essential to identify those individualswho don’t respond to chemotherapy early “to avoid ineffective therapiesand unnecessary side effects,” he noted. This ability to individualizetreatment gives patients and physicians options not previouslyavailable, added Avril, indicating that additional studies are neededto determine how to use 18F-FDG PET in a clinical setting.

PET is a powerful medical imaging procedure that noninvasivelydemonstrates the function of organs and other tissues. It is usedprimarily as a diagnostic tool in cardiology, neurology, oncology andmany other medical specialties. To image cancer, a radiopharmaceuticalsuch as fluorodeoxyglucose (FDG), which includes both sugar(metabolized at a higher rate by cancer cells) and a radionuclide, isinjected into the patient. Because cancer cells metabolize sugar athigher rates than normal cells, the radiopharmaceutical is drawn inhigher concentrations to cancerous areas. The PET scan shows where theradiopharmaceutical is by tracking the gamma ray signals given off bythe radionuclides.

Avril co-wrote “Early Prediction of Response to Chemotherapy in Metastatic Breast Cancer Using Sequential 18F-FDGPET” with Joerg Dose Schwarz, M.D., Michael Bader, M.D., GabrieleHemminger, M.D., and Fritz Janicke, M.D., department of gynecology, andLars Jenicke, M.D., department of nuclear medicine, all at theUniversity Hospital Hamburg-Eppendorf, Hamburg, Germany.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients." ScienceDaily. ScienceDaily, 8 August 2005. <www.sciencedaily.com/releases/2005/08/050807235546.htm>.
Society of Nuclear Medicine. (2005, August 8). PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2005/08/050807235546.htm
Society of Nuclear Medicine. "PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2005/08/050807235546.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins