Featured Research

from universities, journals, and other organizations

PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients

Date:
August 8, 2005
Source:
Society of Nuclear Medicine
Summary:
The effectiveness of chemotherapy in patients with advanced breast cancer can be evaluated earlier by using 18F-FDG positron emission tomography (PET) imaging over other conventional imaging procedures, according to an article in the July issue of the Society of Nuclear Medicine's Journal of Nuclear Medicine.

RESTON, Va.—The effectiveness of chemotherapy in patients with advanced breast cancer can be evaluated earlier by using 18F-FDG positron emission tomography (PET) imaging over other conventional imaging procedures, according to an article in the July issue of the Society of Nuclear Medicine’s Journal of Nuclear Medicine.

PET imaging performed at baseline and after the initiation of treatment “allowed prediction of response as early as after the first cycle of chemotherapy,” said Norbert Avril, M.D., chief of the division of nuclear medicine at the University of Pittsburgh Medical Center, Pittsburgh, Pa. Conventional imaging procedures, such as computed tomography (CT), magnetic resonance imaging (MRI), plain film radiography and ultrasound, do not reliably predict therapy response early in the course of treatment, explained the co-author of “Early Prediction of Response to Chemotherapy in Metastatic Breast Cancer Using Sequential 18F-FDG PET.”

Metastatic breast cancer is the most advanced stage of breast cancer. Cancer cells have spread past the breast and underarm lymph nodes to other areas of the body, continuing to grow, multiply and possibly spread to other regions of the body. Chemotherapy, which uses drugs to stop the growth of cancer cells, either by killing the cells or stopping the cells from dividing, is typically used with patients. At this advanced stage of the disease, the aim of treatment is to improve survival and quality of life, since the disease is generally not curable, said Avril. It’s essential to identify those individuals who don’t respond to chemotherapy early “to avoid ineffective therapies and unnecessary side effects,” he noted. This ability to individualize treatment gives patients and physicians options not previously available, added Avril, indicating that additional studies are needed to determine how to use 18F-FDG PET in a clinical setting.

PET is a powerful medical imaging procedure that noninvasively demonstrates the function of organs and other tissues. It is used primarily as a diagnostic tool in cardiology, neurology, oncology and many other medical specialties. To image cancer, a radiopharmaceutical such as fluorodeoxyglucose (FDG), which includes both sugar (metabolized at a higher rate by cancer cells) and a radionuclide, is injected into the patient. Because cancer cells metabolize sugar at higher rates than normal cells, the radiopharmaceutical is drawn in higher concentrations to cancerous areas. The PET scan shows where the radiopharmaceutical is by tracking the gamma ray signals given off by the radionuclides.

Avril co-wrote “Early Prediction of Response to Chemotherapy in Metastatic Breast Cancer Using Sequential 18F-FDG PET” with Joerg Dose Schwarz, M.D., Michael Bader, M.D., Gabriele Hemminger, M.D., and Fritz Janicke, M.D., department of gynecology, and Lars Jenicke, M.D., department of nuclear medicine, all at the University Hospital Hamburg-Eppendorf, Hamburg, Germany.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients." ScienceDaily. ScienceDaily, 8 August 2005. <www.sciencedaily.com/releases/2005/08/050807235546.htm>.
Society of Nuclear Medicine. (2005, August 8). PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2005/08/050807235546.htm
Society of Nuclear Medicine. "PET Can Identify Effectiveness Of Chemotherapy Early In High-risk Breast Cancer Patients." ScienceDaily. www.sciencedaily.com/releases/2005/08/050807235546.htm (accessed April 19, 2014).

Share This



More Health & Medicine News

Saturday, April 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins