Featured Research

from universities, journals, and other organizations

Promising Therapies For Haemophilia & Heart Disease

Date:
August 11, 2005
Source:
Research Australia
Summary:
Professor Denisa Wagner and her Harvard colleagues have made ground-breaking discoveries that provide hope of an alternative treatment option for haemophilia sufferers.

Haemophilia is a hereditary blood disease, primarily affecting males,where the blood fails to clot causing potentially life-threatening'bleeds'. About one in 6000 Australian males is born with haemophiliain severe, moderate or mild form. People with haemophilia rely onintravenous infusion of recombinant Factor VIII clotting protein.

Professor Denisa Wagner and her Harvard colleagues have madeground-breaking discoveries that provide hope of an alternativetreatment option for haemophilia sufferers.

Presenting this research, at the XXth Congress of theInternational Society on Thrombosis & Haemostasis in Sydney today,Wagner said, "We have demonstrated that a protein called P-selectin isimportant for blood clotting and altering its levels in the bloodstreamby infusion appears to have great therapeutic potential."

Infusion of P-selectin could provide an affordable and moreeffective means of achieving clotting to stop bleeding incidents inhaemophiliacs. Because they carry it naturally in their bodies,patients are highly unlikely to make antibodies against P-selectin.P-selectin also has a longer half-life than clotting factors sotreatment is likely to be less frequent.

"This promises to be a much easier and more effective approach for sufferers, particularly children," said Wagner.

Wagner went on to report, "Blood clotting is an intricatelybalanced process. Blood clots in the heart or brain can result in aheart attack or stroke. Our studies in mouse models have shown thatinhibition of P-selectin reduces atherosclerosis (hardening of thearteries) and the work of our collaborators shows that the eventsleading to deep vein thrombosis are reduced. P-selectin inhibitors havealso been shown to be anti-thrombotic in early human trials"

Measurement of P-selectin levels in the blood stream mayprovide a new diagnostic tool to identify people at risk of heartdisease and stroke. Levels above baseline could alert clinicians topotentially fatal events. Several pharmaceutical companies are nowsearching for compounds that target P-selectin.

"This would represent a major breakthrough in diagnosing andtreating cardiovascular disease," she said. "There is still a greatdeal to be learned about this protein. This research could contributesignificantly to effective strategies to inhibit or enhance P-selectindepending on clinical need".


Story Source:

The above story is based on materials provided by Research Australia. Note: Materials may be edited for content and length.


Cite This Page:

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Ebola Patient Told Hospital He Was from Liberia

Ebola Patient Told Hospital He Was from Liberia

AP (Oct. 1, 2014) The first Ebola patient diagnosed in the U.S. initially went to a Dallas emergency room last week but was sent home, despite telling a nurse that he had been in disease-ravaged West Africa, the hospital acknowledged Wednesday. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins