Featured Research

from universities, journals, and other organizations

Promising Therapies For Haemophilia & Heart Disease

Date:
August 11, 2005
Source:
Research Australia
Summary:
Professor Denisa Wagner and her Harvard colleagues have made ground-breaking discoveries that provide hope of an alternative treatment option for haemophilia sufferers.

Haemophilia is a hereditary blood disease, primarily affecting males,where the blood fails to clot causing potentially life-threatening'bleeds'. About one in 6000 Australian males is born with haemophiliain severe, moderate or mild form. People with haemophilia rely onintravenous infusion of recombinant Factor VIII clotting protein.

Professor Denisa Wagner and her Harvard colleagues have madeground-breaking discoveries that provide hope of an alternativetreatment option for haemophilia sufferers.

Presenting this research, at the XXth Congress of theInternational Society on Thrombosis & Haemostasis in Sydney today,Wagner said, "We have demonstrated that a protein called P-selectin isimportant for blood clotting and altering its levels in the bloodstreamby infusion appears to have great therapeutic potential."

Infusion of P-selectin could provide an affordable and moreeffective means of achieving clotting to stop bleeding incidents inhaemophiliacs. Because they carry it naturally in their bodies,patients are highly unlikely to make antibodies against P-selectin.P-selectin also has a longer half-life than clotting factors sotreatment is likely to be less frequent.

"This promises to be a much easier and more effective approach for sufferers, particularly children," said Wagner.

Wagner went on to report, "Blood clotting is an intricatelybalanced process. Blood clots in the heart or brain can result in aheart attack or stroke. Our studies in mouse models have shown thatinhibition of P-selectin reduces atherosclerosis (hardening of thearteries) and the work of our collaborators shows that the eventsleading to deep vein thrombosis are reduced. P-selectin inhibitors havealso been shown to be anti-thrombotic in early human trials"

Measurement of P-selectin levels in the blood stream mayprovide a new diagnostic tool to identify people at risk of heartdisease and stroke. Levels above baseline could alert clinicians topotentially fatal events. Several pharmaceutical companies are nowsearching for compounds that target P-selectin.

"This would represent a major breakthrough in diagnosing andtreating cardiovascular disease," she said. "There is still a greatdeal to be learned about this protein. This research could contributesignificantly to effective strategies to inhibit or enhance P-selectindepending on clinical need".


Story Source:

The above story is based on materials provided by Research Australia. Note: Materials may be edited for content and length.


Cite This Page:

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins