Featured Research

from universities, journals, and other organizations

Nicotine Exposure Can Increase Motivation To Respond For Food Weeks After The Last Exposure

Date:
September 1, 2005
Source:
Yale University
Summary:
A study provides insight into one of the most vexing issues relating to smoking cessation, one that discourages many people from attempting to quit smoking, the prospect of weight gain.

New Haven, Conn.- A new study by Yale researchers shows that priornicotine exposure in mice can increase their motivation to workfor food, weeks after their last exposure to nicotine, a finding thatruns counter to the popular belief that nicotine exposure curbsappetite.

Related Articles


The study, to be published in an upcoming issue ofPsychopharmacology, also sheds new light on the role played by certainnicotinic acetylcholine receptors when it comes to the reinforcingaspects of nicotine.

The study provides insight into one of the most vexing issues relatingto smoking cessation, one that discourages many people from attemptingto quit smoking, the prospect of weight gain. "Although acute nicotinecan act as an appetite suppressant, these data are the first to suggestthat repeated exposure to nicotine has the opposite effect, thatnicotine increases motivation for food for weeks following exposure tothe drug," said Darlene Brunzell, associate research scientist in theDepartment of Psychiatry and first author of the study.

"This research suggests that when young people take up smoking toregulate their weight, this may be counterproductive in addition tobeing harmful to their health," said Stephanie O'Malley, professor ofpsychiatry and principal investigator for the Center for Nicotine &Tobacco Use Research at Yale. "More research is needed to determine howexactly that works, but this does show that there could be a connectionbetween exposure to nicotine and subsequent weight gain in someindividuals."

In addition, the study identifies which nicotinic receptors areinvolved in nicotine's control over cues. "We knew previously that cuesplay a critical role in nicotine and tobacco consumption in animals andhumans," said Brunzell. "These studies show that Beta 2 nicotinicreceptors are necessary for nicotine's ability to increase the controlthat cues have over behavior." said Dr. Darlene Brunzell, Ph.D., firstauthor of the study. he also said, in addition, that the findings runcounter to the popular belief that acute nicotine exposure curbsappetite. "These data are the first to suggest that repeated exposureto nicotine has the opposite effect, that nicotine increases motivationfor food for weeks following exposure to the drug."

O'Malley said that the research has significance when it comes todeveloping solutions for smokers who gain weight after they quitsmoking. She noted that weight concerns keep many people, particularlywomen, from attempting to quit. Any information about the mechanism forweight gain could help the researchers at Yale and elsewhere figure outhow to address that concern. In the meantime, she said, the researchmight help discourage people from starting to smoke to regulate theirweight.

###

For more information about CENTURY/TTURC, please see www.quitwithyale.org


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Nicotine Exposure Can Increase Motivation To Respond For Food Weeks After The Last Exposure." ScienceDaily. ScienceDaily, 1 September 2005. <www.sciencedaily.com/releases/2005/09/050901073320.htm>.
Yale University. (2005, September 1). Nicotine Exposure Can Increase Motivation To Respond For Food Weeks After The Last Exposure. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2005/09/050901073320.htm
Yale University. "Nicotine Exposure Can Increase Motivation To Respond For Food Weeks After The Last Exposure." ScienceDaily. www.sciencedaily.com/releases/2005/09/050901073320.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Yoga Could Be As Beneficial For The Heart As Walking, Biking

Newsy (Dec. 17, 2014) Yoga can help your weight, blood pressure, cholesterol and heart just as much as biking and walking does, a new study suggests. Video provided by Newsy
Powered by NewsLook.com
1st Responders Trained for Autism Sensitivity

1st Responders Trained for Autism Sensitivity

AP (Dec. 16, 2014) More departments are ordering their first responders to sit in on training sessions that focus on how to more effectively interact with those with autism spectrum disorder (Dec. 16) Video provided by AP
Powered by NewsLook.com
Guys Are Idiots, According To Sarcastic Study

Guys Are Idiots, According To Sarcastic Study

Newsy (Dec. 12, 2014) A study out of Britain suggest men are more idiotic than women based on the rate of accidental deaths and other factors. Video provided by Newsy
Powered by NewsLook.com
Believing in Father Christmas Good for Children's Imaginations

Believing in Father Christmas Good for Children's Imaginations

AFP (Dec. 12, 2014) As the countdown to Christmas gets underway, so too does the Father Christmas conspiracy. But psychologists say that telling our children about Santa, flying reindeer and elves is good for their imaginations. Duration: 01:57 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins