Featured Research

from universities, journals, and other organizations

GABA Halts Stem Cell Production In The Brain

Date:
September 3, 2005
Source:
Yale University
Summary:
Release of the neurotransmitter GABA by adult neuronal precursor cells that develop into neurons limits stem cell proliferation.

New Haven, Conn.--Release of the neurotransmitter GABA by adultneuronal precursor cells that develop into neurons limits stem cellproliferation, according to a study at Yale School of Medicine in theSeptember issue of Nature Neuroscience.

Related Articles


Tight regulation of new cell growth in the adult brain is criticalsince uncontrolled proliferation can lead to devastating diseases, suchas cancer.

"The GABAergic signaling described in our paper allows aproper balance between stem cells and daughter cells, and preventsout-of-control proliferation of stem cells," said Angelique Bordey,assistant professor in the Departments of Neurosurgery and Cellular& Molecular Physiology, and senior author of the study. "The nextquestion we would like to answer is what would happen if this signalingwas disrupted in a living being."

Neural stem cells in the subventricular zone of the brain arethought to give rise to glioma, or brain tumors, when theirproliferation is out of control, she said. "One of the goals of thisline of research is to find ways to promote neurogenesis in acontrolled manner, so identifying signaling pathways, factors andreceptors that block or promote neurogenesis is very important," Bordeysaid. "These factors and receptors provide additional sites forpharmaceutical targets to promote neurogenesis and self-renewal ofdying cells."

Alternatively, identifying negative GABAergic signaling onstem cell proliferation, as the researchers did in this study, suggeststhat any drugs that would enhance GABA's function may limitneurogenesis, she said.

"GABAergic drugs such as alcohol and benzodiazepines (somesleeping pills) have been used by a large number of individuals in oursociety and these drugs are expected to block stem cell proliferation,"Bordey said. "Such an impact of these drugs on neurogenesis and brainfunction would be the next step to investigate."

###

Co-authors include Xiuxin Liu and Qin Wang of Yale and Tarik Haydar of George Washington University School of Medicine.

Nature Neuroscience 8: 1179-1187 (September 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "GABA Halts Stem Cell Production In The Brain." ScienceDaily. ScienceDaily, 3 September 2005. <www.sciencedaily.com/releases/2005/09/050902072541.htm>.
Yale University. (2005, September 3). GABA Halts Stem Cell Production In The Brain. ScienceDaily. Retrieved November 1, 2014 from www.sciencedaily.com/releases/2005/09/050902072541.htm
Yale University. "GABA Halts Stem Cell Production In The Brain." ScienceDaily. www.sciencedaily.com/releases/2005/09/050902072541.htm (accessed November 1, 2014).

Share This



More Health & Medicine News

Saturday, November 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins