Featured Research

from universities, journals, and other organizations

Human Muscle-derived Stem Cells Effective In Animal Models Of Incontinence

Date:
September 2, 2005
Source:
University of Pittsburgh Medical Center
Summary:
Human muscle-derived cells, pluripotent stem cells found in muscle, have been used to cure stress urinary incontinence in animal models, a finding which signals that these cells are prime candidates to treat the condition in adults. The research will be presented by University of Pittsburgh researchers at the annual meeting of the International Continence Society Aug. 29 through Sept. 2 in Montreal.

MONTREAL, Aug. 31 -- Human muscle-derived cells, pluripotent stem cellsfound in muscle, have been used to cure stress urinary incontinence inanimal models, a finding which signals that these cells are primecandidates to treat the condition in adults. The research will bepresented by University of Pittsburgh researchers at the annual meetingof the International Continence Society Aug. 29 through Sept. 2 inMontreal.

In the study, the Pittsburgh researchers led by Michael Chancellor,M.D., injected the human muscle-derived stem cells into theperiurethral muscle of a well-established animal model for stressurinary incontinence. After four weeks, the models' leak-pointpressure, the pressure at which urine would leak from the bladder, hadbeen restored to levels that would be seen normally.

"In past studies we have shown that muscle-derived cells fromrats have been able to restore deficient muscle in the bladder. Usinghuman muscle-derived cells was the next step in bringing this therapyto humans," said Dr. Chancellor, who is professor of urology at theUniversity of Pittsburgh School of Medicine.

Researchers believe that the human muscle-derived cells wereable to restore leak-point pressure to normal levels by differentiatinginto new muscle fibers, which prevented periurethral muscle atrophy.They will be returning to the lab to identify exactly how these cellswork to regenerate muscle.

Clinical trials using muscle-derived cell therapy for incontinence have recently begun in Toronto.

Urinary incontinence affects 13 million Americans. Those withstress urinary incontinence involuntarily lose urine while doingactivities that put stress on the abdomen, such as laughing, sneezing,coughing, lifting or walking. A result of damage to the urethralsphincter, stress incontinence is most often caused by childbirth,menopause or pelvic surgery.

###

Results are published in abstract 2.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "Human Muscle-derived Stem Cells Effective In Animal Models Of Incontinence." ScienceDaily. ScienceDaily, 2 September 2005. <www.sciencedaily.com/releases/2005/09/050902073119.htm>.
University of Pittsburgh Medical Center. (2005, September 2). Human Muscle-derived Stem Cells Effective In Animal Models Of Incontinence. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2005/09/050902073119.htm
University of Pittsburgh Medical Center. "Human Muscle-derived Stem Cells Effective In Animal Models Of Incontinence." ScienceDaily. www.sciencedaily.com/releases/2005/09/050902073119.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins