Featured Research

from universities, journals, and other organizations

Eating And Body Weight Regulated By Specific Neurons

Date:
September 13, 2005
Source:
Yale University
Summary:
Researchers at Yale School of Medicine provide direct evidence that two parts of a neuronal system, one that promotes eating and another that suppresses eating, are critical for the acute regulation of eating and body weight, according to a study published online in the September 11 issue of Nature Neuroscience.

Researchers at Yale School of Medicine provide direct evidence that twoparts of a neuronal system, one that promotes eating and another thatsuppresses eating, are critical for the acute regulation of eating andbody weight, according to a study published online in the September 11issue of Nature Neuroscience.

Related Articles


The paper makes it clear that the agouti-related peptide-expressing(AgRP) neurons are mandatory for eating. "Previous studies showed thatthe brain, particularly the hypothalamus, is responsible for theregulation of eating," said co-senior author Tamas Horvath, chair andassociate professor in the Section of Comparative Medicine, andassociate professor in neurobiology and the Department of Obstetrics,Gynecology & Reproductive Sciences. "But until now, no experimentalevidence was available to prove that AgRP neurons are critical foracute regulation of eating."

Horvath's collaborator Jens Bruening of the University of Cologne inGermany introduced the avian diphtheria toxin receptor into neurons inthe feeding support system of transgenic mice. When the animals wereadults, two injections of toxin caused the specific cell population todie within 48 hours, impairing the mouse's ability to eat and resultingin acute anorexia. These mice also showed marked reduction in bloodglucose, plasma insulin and Leptin concentrations.

"Our results confirm the hypothesis that these two systems are criticalfor eating and the cessation of eating," said Horvath. "Previoustransgenic approaches failed to provide this proof because ofcompensatory mechanisms that could operate during development. None ofthose actually knocked out neuronal function. In this case, however,neurons are gone and there is no time to replace their function."

In explaining the significance of the finding, Horvath said, "It isimportant to ensure that the multibillion dollar academic andpharmaceutical approach against metabolic disorders is leaning in theright direction. The approach in general could also eventually lead tospecific destruction of cells in other kinds of diseases."

Other authors on the study included Eva Gropp, Marya Shanabrough,Erzsebet Borak, Allison W. Xu, Ruth Janoschek, Thorsten Buch, LeonaPlum, Nina Balthasar, Brigitte Hampel, Ari Waisman, Gregory S. Barsh,and co-senior author Jens Bruning.

###

Citation: Nature Neuroscience, Published online September 11, in print: October 2005 Vol. 8 No. 10


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Eating And Body Weight Regulated By Specific Neurons." ScienceDaily. ScienceDaily, 13 September 2005. <www.sciencedaily.com/releases/2005/09/050913124631.htm>.
Yale University. (2005, September 13). Eating And Body Weight Regulated By Specific Neurons. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2005/09/050913124631.htm
Yale University. "Eating And Body Weight Regulated By Specific Neurons." ScienceDaily. www.sciencedaily.com/releases/2005/09/050913124631.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
Study Shows Newborn Chicks Count From Left to Right Just Like Humans

Study Shows Newborn Chicks Count From Left to Right Just Like Humans

Buzz60 (Jan. 30, 2015) Researchers for the first time identified human&apos;s innate preference for associating low and high numbers with the left and right respectively in another species. Jen Markham (@jenmarkham) explains. Video provided by Buzz60
Powered by NewsLook.com
Best Mood Elevating, Feel Good Shakes & Smoothies

Best Mood Elevating, Feel Good Shakes & Smoothies

Buzz60 (Jan. 30, 2015) You can elevate your mood by having a meal in a glass. Fitness and nutrition expert John Basedow (@JohnBasedow) offers the best &apos;feel good&apos; smoothies and shakes chock full of depression-relieving ingredients...including apples, berries, lemons, cucumbers, papaya, kiwi, spinach, kale, whey protein, matcha, ginger, turmeric and cinnamon. Video provided by Buzz60
Powered by NewsLook.com
Poll Says Firstborn Is Responsible, Youngest Is Funnier

Poll Says Firstborn Is Responsible, Youngest Is Funnier

Newsy (Jan. 30, 2015) According to a poll out of the U.K., eldest siblings feel more responsible and successful than their younger siblings. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins