Featured Research

from universities, journals, and other organizations

Aortic Aneurysm Associated With Decreased Incidence Of Atherosclerosis

Date:
September 13, 2005
Source:
Yale University
Summary:
Oddly enough, having an aneurysm in the ascending aorta is significantly associated with decreased incidence of atherosclerosis, according to a study by Yale School of Medicine researchers published this month in Chest. An aortic aneurysm is a widening of the major artery leading from the heart that may rupture, causing hemorrhage, or may split into layers, jeopardizing blood flow to internal organs. When split into layers it is called "aortic dissection."

New Haven, Conn. -- Oddly enough, having an aneurysm in theascending aorta is significantly associated with decreased incidence ofatherosclerosis, according to a study by Yale School of Medicineresearchers published this month in Chest.

An aortic aneurysm is a widening of the major artery leading fromthe heart that may rupture, causing hemorrhage, or may split intolayers, jeopardizing blood flow to internal organs. When split intolayers it is called "aortic dissection."

"This is a silver lining in the cloud of aneurysm disease,"said John Elefteriades, M.D., section chief of cardiothoracic surgeryin the Department of Surgery and senior author of the study.

He said the study was prompted by clinical observations thatpatients with aortic aneurysm and dissection-men and women, young andelderly-had a noteworthy absence of atherosclerosis. Most patients,Elefteriades said, begin showing the earliest signs of atherosclerosisin their 20s. "Surprisingly, the arteries of the patients withascending aortic aneurysm looked like a baby's or a young child's," hesaid.

This study included 64 patients between 36 and 82 years of agewith aortic aneurysm or dissection. The control group consisted of 86trauma patients who had undergone computerized tomography of the chest.The lower prevalence of calcification in patients with ascending aorticaneurysm and dissection was independent of the major risk factors forheart disease-age, gender, high cholesterol, hypertension, diabetes andsmoking history. In fact, the aneurysm patients appeared to besignificantly protected despite a higher cholesterol level.

In earlier studies Elefteriades and his colleaguesdemonstrated the heritable nature of ascending aortic aneurysm anddissection. He said it is conceivable that the mutations inherent inaortic aneurysm also play a role in the atherosclerotic process.

"If patients with certain heritable aortic pathologies exhibitdecreased systemic atherosclerosis, this finding would be important byvirtue of providing new insights into the pathophysiology of the mostcommon cause of death in the western world, heart and blood vesseldisease due to atherosclerosis," he said.

###

Chest: (September 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Aortic Aneurysm Associated With Decreased Incidence Of Atherosclerosis." ScienceDaily. ScienceDaily, 13 September 2005. <www.sciencedaily.com/releases/2005/09/050913124719.htm>.
Yale University. (2005, September 13). Aortic Aneurysm Associated With Decreased Incidence Of Atherosclerosis. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2005/09/050913124719.htm
Yale University. "Aortic Aneurysm Associated With Decreased Incidence Of Atherosclerosis." ScienceDaily. www.sciencedaily.com/releases/2005/09/050913124719.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins