Featured Research

from universities, journals, and other organizations

Combination Treatment Enhances Tetanus Vaccination

Date:
September 15, 2005
Source:
Penn State
Summary:
In studies with mice, Penn State researchers have shown that a combination of retinoic acid -- a product the body makes naturally from vitamin A -- and PIC, a synthetic immunity booster, significantly elevates the immune system response to a tetanus shot.

In studies with mice, Penn State researchers have shown that acombination of retinoic acid -- a product the body makes naturally fromvitamin A -- and PIC, a synthetic immunity booster, significantlyelevates the immune system response to a tetanus shot.

Related Articles


Dr. A. Catharine Ross, who holds the Dorothy Foehr Huck Chair inNutrition at Penn State, directed the study. She says, "There aren'tvery many examples of using nutrition to improve immune response. Theseresults show that a natural product of vitamin A can have an importantrole in regulating immunity and, when administered along with PIC,might be a potentially powerful nutritional-immunological assist invaccination."

The researchers reported their findings today (Monday, Sept.12) in the online early edition of the Proceedings of the NationalAcademy of Sciences. The paper is "The anti-tetanus immune response ofneonatal mice is augmented by retinoic acid combined withpolyriboinosinic:polyribocytidylic acid." The first author is Yifan Ma,doctoral candidate in the Graduate Program in Integrative Biosciences,the Department of Nutritional Sciences and the Huck Institute for LifeSciences.

In previous studies, the Penn State researchers had shown thatretinoic acid boosts the adult mouse response to the tetanus vaccine.In the current investigation, they studied the response in week-oldmice. Mouse pups, like human infants, have a weaker response tovaccination than do adults due to the immaturity of their immunesystem.

Ross notes, "Strategies to enhance vaccination efficiency in early life are highly sought."

In the most recent Penn State experiments, week-old mice weregiven oral doses of retinoic acid along with a tetanus shot. The pupsthat received the retinoic acid developed a four times better immuneresponse than mice that didn't receive the vitamin A product. Mice thatreceived both retinoic acid and, PIC, the synthetic immunity boosterpolyriboinosinic: polyribocytidylic acid, developed a seven timeshigher immune response.

In addition, the researchers found that the combined retinoicacid/PIC treatment produced a more balanced enhancement than eitherretinoic acid or PIC alone.

Ross explains that the researchers measured three subtypes oftetanus antibodies in blood samples from the mouse pups aftervaccination. Both retinoic acid and PIC, when administered alone, eachincreased the antibodies about four-fold over all but the combinationretinoic acid/PIC treatment resulted in elevated levels that hadproportions of antibody types most like untreated pups.

Vitamin A is already given to children who are deficient inthis vitamin when they receive the measles ordiptheria-pertussis-tetanus vaccination and the intervention has beenshown to significantly elevate the vaccine-induced antibody responses.However, dosing non-deficient children with vitamin A cannot beexpected to have the same results as retinoic acid.

Ross explains that the human body makes retinoic acid fromingested vitamin A in very controlled amounts. Eating higher amounts ofvitamin A doesn't automatically result in higher levels of retinoicacid in the body.

###

The research was supportedby a grant from the National Institute of Health, the Penn State HuckInstitute for the Life Sciences and the Dorothy Foehr Huck Chair inNutrition.


Story Source:

The above story is based on materials provided by Penn State. Note: Materials may be edited for content and length.


Cite This Page:

Penn State. "Combination Treatment Enhances Tetanus Vaccination." ScienceDaily. ScienceDaily, 15 September 2005. <www.sciencedaily.com/releases/2005/09/050915002122.htm>.
Penn State. (2005, September 15). Combination Treatment Enhances Tetanus Vaccination. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2005/09/050915002122.htm
Penn State. "Combination Treatment Enhances Tetanus Vaccination." ScienceDaily. www.sciencedaily.com/releases/2005/09/050915002122.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins