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Breast Tumors In Mice Eradicated Using Cancer Vaccine

Date:
September 15, 2005
Source:
University of Pennsylvania School of Medicine
Summary:
A team from the University of Pennsylvania School of Medicine has shown that by using a cancer vaccine based on the bacterium Listeria monocytogenes, they can cure mice with established breast tumors. Using Listeria, the researchers, delivered the tumor-associated antigen HER-2/Neu to immune cells. HER-2/Neu is overexpressed in 20 to 40 percent of all breast cancers. These cells eventually enlist killer T cells to destroy the tumor cells that display the HER-2/Neu molecule.

Listeria inside a macrophage, an immune cell enlisted in the immune response.
Credit: Paul Neeson, PhD, University of Pennsylvania School of Medicine


Story Source:

The above story is based on materials provided by University of Pennsylvania School of Medicine. Note: Materials may be edited for content and length.


Cite This Page:

University of Pennsylvania School of Medicine. "Breast Tumors In Mice Eradicated Using Cancer Vaccine." ScienceDaily. ScienceDaily, 15 September 2005. <www.sciencedaily.com/releases/2005/09/050915004756.htm>.
University of Pennsylvania School of Medicine. (2005, September 15). Breast Tumors In Mice Eradicated Using Cancer Vaccine. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2005/09/050915004756.htm
University of Pennsylvania School of Medicine. "Breast Tumors In Mice Eradicated Using Cancer Vaccine." ScienceDaily. www.sciencedaily.com/releases/2005/09/050915004756.htm (accessed April 19, 2014).

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