Featured Research

from universities, journals, and other organizations

Breast Cancer Advance

Date:
September 17, 2005
Source:
University of East Anglia
Summary:
A new family of genes could hold the key to winning the battle against breast cancer, according to new research at the University of East Anglia.

Cancer specialists at the University of East Anglia have discovered that several 'ADAMTS' genes are turned off in breast cancer compared to normal breast tissue, while others are switched on. These genes could be targets for the development of 'smart' drugs tailored to treat individual patients' tumours.

The ADAMTS genes are recent additions to a large family known as the metalloproteinases -- many of which can break down tissues and have therefore been linked with tumour metastasis, or spread, through the body. However, the ADAMTS group had not previously been linked to the development of breast cancer. These new findings suggest they could become robust 'markers', predicting disease outcome in breast cancer patients and identifying those patients most at risk of recurrence of the disease.

Funded by Breast Cancer Campaign, the innovative three-year study has been undertaken by Dr Sarah Porter and Prof Dylan Edwards of UEA's School of Biological Sciences, using tissue samples from patients at the Norfolk and Norwich University Hospital and a medical centre in Nijmegen in The Netherlands. The findings have just been published in the International Journal of Cancer.

"We are beginning to understand how genes contribute to breast cancer development and I am confident this work will ultimately prove valuable for both diagnosis and treatment of the disease," said Prof Edwards.

Pamela Goldberg, Breast Cancer Campaign chief executive, said: "The spread of breast cancer around the body is the single most important factor in breast cancer mortality. The findings of this research will play a major role in improving the future of breast cancer treatment which will focus on drug regimes tailored to the individual patient."

Earlier published work by Dr Porter and Prof Edwards showed that 11 of the 19 ADAMTS genes in humans are significantly altered as breast cancer develops. Their latest research now focuses on two of the genes, ADAMTS8 and ADAMTS15, and has shown that they can help to predict disease outcome in breast cancer patients. These new findings show that differing levels of activity of these genes means that patients can be grouped into one of four categories. These categories could be used to predict the likelihood of the breast cancer recurring. Those in the highest risk category are three times more likely to have a recurrence of breast cancer, and over five times more likely to die from the disease, than patients in the lowest risk category.

The UEA team hope that, in the future, clinicians will look at the levels of ADAMTS genes in a patient's tumour and be able to prescribe the most effective therapy for treating the disease.


Story Source:

The above story is based on materials provided by University of East Anglia. Note: Materials may be edited for content and length.


Cite This Page:

University of East Anglia. "Breast Cancer Advance." ScienceDaily. ScienceDaily, 17 September 2005. <www.sciencedaily.com/releases/2005/09/050917085400.htm>.
University of East Anglia. (2005, September 17). Breast Cancer Advance. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2005/09/050917085400.htm
University of East Anglia. "Breast Cancer Advance." ScienceDaily. www.sciencedaily.com/releases/2005/09/050917085400.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins