Featured Research

from universities, journals, and other organizations

Adult Sickle Cell Drug Proves Effective In Young Children

Date:
September 20, 2005
Source:
American Society of Hematology
Summary:
A drug used for the treatment of sickle cell anemia in adults has now been shown to cause significant improvements in very young children with the disorder. The finding is an important one as these young patients are especially vulnerable to serious organ failure and even death at an early age. The study results will be published in the October 1, 2005, issue of Blood, the official journal of the American Society of Hematology.

(WASHINGTON, September 19, 2005) -- A drug used for the treatment ofsickle cell anemia in adults has now been shown to cause significantimprovements in very young children with the disorder. The finding isan important one as these young patients are especially vulnerable toserious organ failure and even death at an early age. The study resultswill be published in the October 1, 2005, issue of Blood, the official journal of the American Society of Hematology.

Sickle cell anemia is a genetic blood disorder that can cause severepain, fatigue, and organ damage to the kidneys, spleen, and liver. Itoccurs in about one in every 500 African-Americans. In the new study,21 children from two to four years old who had sickle cell anemia weregiven the drug hydroxyurea orally as a flavored liquid formula. Amajority of the children took the drug for at least four years and morethan half of the participants completed all six years of the study.

The treatment was well-tolerated in the patients, with only one child'sdosage permanently reduced during the study due to adverse effects. Thedrug's primary function, to counteract the effects of the disease byincreasing and sustaining fetal hemoglobin production, was achieved inall study participants. Patients treated with hydroxyurea also weighedmore and were taller than untreated children with the disorder -- theirgrowth rates were even comparable to those of normal children.

Another measure of success of the therapy was that the study patientshad improved spleen function, an important finding as many childrenwith sickle cell anemia lose spleen function by two years of age.Participants also experienced significantly fewer incidents of acutechest syndrome, a potentially life-threatening disorder associated withsickle cell disease. During the study, one four-year-old girl died ofsepsis, a toxic bacterial infection, though no increased risk of sepsiswas found among the hydroxyurea-treated patients.

"This study demonstrates that hydroxyurea is an efficient and safetreatment option for young children with sickle cell anemia," said JaneHankins, M.D., M.S., of St. Jude Comprehensive Sickle Cell Center andlead study author. "As sickle cell anemia is a chronic disorder, havinga drug that can be started early and continued long-term with fewadverse effects is of significant importance to the way we treat thisdebilitating disease."

###

This work was supported by the American Lebanese Syrian AssociatedCharities and by General Clinical Research Center grants from theNational Institutes of Health.

###

The American Society of Hematology (www.hematology.org)is the world's largest professional society concerned with the causesand treatment of blood disorders. Its mission is to further theunderstanding, diagnosis, treatment, and prevention of disordersaffecting blood, bone marrow, and the immunologic, hemostatic, andvascular systems, by promoting research, clinical care, education,training, and advocacy in hematology.

Blood, the official journal of the American Society of Hematology, is the most cited peer-reviewed publication in the field. Blood is issued to Society members and other subscribers twice per month, available in print and online at www.bloodjournal.org.


Story Source:

The above story is based on materials provided by American Society of Hematology. Note: Materials may be edited for content and length.


Cite This Page:

American Society of Hematology. "Adult Sickle Cell Drug Proves Effective In Young Children." ScienceDaily. ScienceDaily, 20 September 2005. <www.sciencedaily.com/releases/2005/09/050920081131.htm>.
American Society of Hematology. (2005, September 20). Adult Sickle Cell Drug Proves Effective In Young Children. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2005/09/050920081131.htm
American Society of Hematology. "Adult Sickle Cell Drug Proves Effective In Young Children." ScienceDaily. www.sciencedaily.com/releases/2005/09/050920081131.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins