Featured Research

from universities, journals, and other organizations

Advances In Brain Imaging For Epilepsy

Date:
September 22, 2005
Source:
American Neurological Association
Summary:
Positron emission tomography (PET) brain scans of a brain chemical messenger system may prove sensitive enough to help plan brain surgery for epilepsy, according to a study presented at the 130th annual meeting of the American Neurological Association in San Diego.

San Diego -- Positron emission tomography (PET) brain scans of a brainchemical messenger system may prove sensitive enough to help plan brainsurgery for epilepsy, according to a study presented at the 130thannual meeting of the American Neurological Association in San Diego.

"Our preliminary data suggest that PET imaging with a marker thatshows deficits in signaling for the neurotransmitter serotonin is moresensitive than the traditional PET measurement of brain glucose," saidsenior author William H. Theodore MD, chief of the Clinical EpilepsySection at the National Institutes of Neurological Disorders andStroke.

When drugs fail to control epilepsy, brain surgery is often theonly remaining therapeutic option. However, identifying the correctspot for surgery has traditionally required a separate preliminary --and inherently risky -- surgical procedure.

Epilepsy is a chronic illness of the brain that is estimated toaffect almost one percent of the U.S. population. During an epilepticseizure, nerve cells in the brain fire electrical impulses much fasterthan normal, often leading to loss of consciousness.and convulsions

In a subset of cases, the seizures always begin the same,identifiable area of the brain, then spread to other areas. Surgery toremove the area where seizures start can be safe and effective.

"About 30% of patients with epilepsy, or approximately 600,000people in the U.S., have seizures that are not controlled byantiepileptic drugs. Surgery may be an option for some of these, andlocalizing the epileptic focus is crucial," said Theodore.

Both PET and magnetic resonance imaging (MRI) are underinvestigation as tools to guide neurosurgeons to areas of the brainwhere epileptic seizures originate.

Theodore and colleagues at NINDS have found, in their pilotstudy, that a marker for serotonin systems was able to identifyepilepsy-generating brain areas even in a patient with a normal MRI.

In related studies, the researchers have found that thesedeficits in serotonin correlate with the likelihood that patients withepilepsy will also suffer from depression.

Theodore cautions that this is a preliminary study of aprocedure that is still in the research stages. However, he suggeststhat physicians should not hesitate to treat patients with epilepsy anddepression with effective antidepressant drugs, and to refer patientsfor surgical evaluation if seizures are not controlled by antiepilepticdrugs.

###

Serotonin 1A receptor imaging and temporal lobectomy.
RobertBonwetsch, MD, Giampiero Giovacchini, MD, Richard Carson, PhD, PatriciaReeves-Tyer, Kathy Kelley, MA, Peter Herscovitch, MD and William HTheodore, MD. Bethesda, Maryland.

Positron emission tomography (PET) may provide supportive datafor detecting epileptogenic zones in patients with temporal lobeepilepsy (TLE), helping to reduce the need for invasive EEG studies.Serotonin (5HT) 1A receptor binding has been shown to be decreased inTLE. We used PET to compare 5HT-1A binding measured with the silentantagonist 18FCWAY, to glucose metabolism measured with 18FDG, in 19patients who had temporal lobectomy for uncontrolled epilepsy, and amean follow-up of 31 months. We analyzed PET data with co-registeredMRI and partial volume correction, computing an asymmetry index (AI)using the formula [2] x [ipsilateral contralateral]/[ipsilateral +contralateral] for anatomic regions drawn on each patient sco-registered MRI scan. Mean FDG asymmetry in the resected region was0.25 0.18, versus 0.47 0.20 for FCWAY (P<0.001). Three patients,including one with normal MRI, had unrevealing FDG PET but a clearFCWAY asymmetry. There was a trend for 13 patients who wereseizure-free to have greater FCWAY (p<0.08), but not FDG AI, than 6patients with persistent seizures. Our preliminary results suggest thatFCWAY PET may be more sensitive than FDG for presurgical evaluation oftemporal lobe epilepsy.


Story Source:

The above story is based on materials provided by American Neurological Association. Note: Materials may be edited for content and length.


Cite This Page:

American Neurological Association. "Advances In Brain Imaging For Epilepsy." ScienceDaily. ScienceDaily, 22 September 2005. <www.sciencedaily.com/releases/2005/09/050922020525.htm>.
American Neurological Association. (2005, September 22). Advances In Brain Imaging For Epilepsy. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2005/09/050922020525.htm
American Neurological Association. "Advances In Brain Imaging For Epilepsy." ScienceDaily. www.sciencedaily.com/releases/2005/09/050922020525.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins