Featured Research

from universities, journals, and other organizations

Potential New Treatment For Insulin-dependent Diabetes

Date:
September 28, 2005
Source:
Journal of Experimental Medicine
Summary:
Scientists in Japan have found a way to improve on a promising diabetes treatment. In the October 3 issue of The Journal of Experimental Medicine, Masaru Taniguchi and colleagues report that transplanted insulin-producing cells survive better when the activation of a specific type of immune cell is blocked.

Scientists in Japan have found a way to improve on a promising diabetestreatment. In the October 3 issue of The Journal of ExperimentalMedicine, Masaru Taniguchi and colleagues report that transplantedinsulin-producing cells survive better when the activation of aspecific type of immune cell is blocked.

Insulin-dependent diabetes is caused by the destruction of theinsulin-producing cells in the pancreas (called islet cells) byauto-reactive T cells. The loss of insulin results in an inability tocontrol blood sugar levels. Transplantation of islet cells is aneffective way to restore insulin production, but this therapy requireslife-long immunosuppression of the patient. Even withimmunosuppression, up to half of the transplanted cells are rapidlydestroyed by the patient's own T cells.

Taniguchi's group used a mouse model to show that a subset of cellsknown as natural killer T (NKT) cells instigates the rapid destructionof the islet cells. NKT cells become activated -- likely in response tothe stress of the transplant procedure -- and produce an inflammatorymolecule called interferon (IFN)-gamma, which helps to activate theauto-reactive T cells. In mice that lack NKT cells or are unable toproduce IFN-gamma, the transplanted cells survived.

The group went on to show that multiple doses of a drug (calledalpha-galactosylceramide), which activates NKT cells in single doses,caused these cells to produce less IFN-gamma. The decreased IFN-gammaproduction protected the transplanted islet cells. The authors thussuggest that multiple doses of the same compound, currently in clinicaltrials in humans, might help prevent the early loss of transplantedislet cells in patients with insulin-dependent diabetes.


Story Source:

The above story is based on materials provided by Journal of Experimental Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Experimental Medicine. "Potential New Treatment For Insulin-dependent Diabetes." ScienceDaily. ScienceDaily, 28 September 2005. <www.sciencedaily.com/releases/2005/09/050928233735.htm>.
Journal of Experimental Medicine. (2005, September 28). Potential New Treatment For Insulin-dependent Diabetes. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2005/09/050928233735.htm
Journal of Experimental Medicine. "Potential New Treatment For Insulin-dependent Diabetes." ScienceDaily. www.sciencedaily.com/releases/2005/09/050928233735.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Nigeria Ups Ebola Stakes on 1st Death

Nigeria Ups Ebola Stakes on 1st Death

Reuters - Business Video Online (July 29, 2014) Nigerian authorities have shut and quarantined a Lagos hospital where a Liberian man died of the Ebola virus, the first recorded case of the highly-infectious disease in Africa's most populous economy. David Pollard reports Video provided by Reuters
Powered by NewsLook.com
Running 5 Minutes A Day Might Add Years To Your Life

Running 5 Minutes A Day Might Add Years To Your Life

Newsy (July 29, 2014) According to a new study, just five minutes of running or jogging a day could add years to your life. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Poses Little Threat To U.S.: CDC

Ebola Outbreak Poses Little Threat To U.S.: CDC

Newsy (July 29, 2014) The Ebola outbreak in West Africa poses little threat to Americans, according to officials with the Centers for Disease Control and Prevention. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins