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First Report Of Cancer Drug Gleevec As New Target Therapy For Pulmonary Hypertension

Date:
September 30, 2005
Source:
University of Giessen Lung Center (UGLC)
Summary:
Today, German scientists of the University of Giessen Lung Center (UGLC) published a case study in the Sept. 29 issue of the New England Journal of Medicine (NEJM). The study reveals that the cancer drug Gleevec (Imatinib) may represent a promising new targeted therapy for patients suffering from pulmonary hypertension.

Gleevec (Imatinib) is a representative of the newest generation of cancer drugs. The substance conveys its potent anti-proliferative effect by selectively supressing the tyrosine kinase pathway. The Giessen lung researchers now issue a first report of this substance as a new target therapy for pulmonary hypertension. "In cancer, tissue proliferation is uncontrolled and leads to the spreading of the tumor," primary investigator Prof. Friedrich Grimminger of the University of Giessen Lung Center explained. "In pulmonary hypertension, also, uncontrolled growth of the vascular wall is the underlying mechanism of the disease." Pulmonary hypertension is a chronic and life-shortening vascular disease characterized by high pressure in the lung blood vessels. The relatively common condition can occur for many reasons such as heart disease and various acute and chronic lung ailments. As a result, the pulmonary arteries thicken and stiffen, causing high blood pressure and right heart hypertrophy.


Story Source:

The above story is based on materials provided by University of Giessen Lung Center (UGLC). Note: Materials may be edited for content and length.


Cite This Page:

University of Giessen Lung Center (UGLC). "First Report Of Cancer Drug Gleevec As New Target Therapy For Pulmonary Hypertension." ScienceDaily. ScienceDaily, 30 September 2005. <www.sciencedaily.com/releases/2005/09/050930082009.htm>.
University of Giessen Lung Center (UGLC). (2005, September 30). First Report Of Cancer Drug Gleevec As New Target Therapy For Pulmonary Hypertension. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2005/09/050930082009.htm
University of Giessen Lung Center (UGLC). "First Report Of Cancer Drug Gleevec As New Target Therapy For Pulmonary Hypertension." ScienceDaily. www.sciencedaily.com/releases/2005/09/050930082009.htm (accessed April 24, 2014).

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