Featured Research

from universities, journals, and other organizations

Researchers At Yale Identify A Genetic Link To Tourette’s Syndrome

Date:
October 13, 2005
Source:
Yale University
Summary:
In what may be a major milestone in Tourette’s Syndrome (TS) research, scientists at Yale School of Medicine and their colleagues have identified a gene called SLITRK1 that appears to contribute to some cases of TS, according to a report in the October 14 issue of Science.

New Haven, Conn. — In what may be a major milestone in Tourette’s Syndrome (TS) research, scientists at Yale School of Medicine and their colleagues have identified a gene called SLITRK1 that appears to contribute to some cases of TS, according to a report in the October 14 issue of Science.

“We now have rare mutations, expression and functional data, all supporting a role for this gene in Tourette’s Syndrome,” said senior author Matthew State, M.D., Harris Assistant Professor in the Yale Child Study Center and in the Department of Genetics at Yale. “This finding could provide an important clue in understanding Tourette’s on a molecular and cellular level. Confirming this, in even a small number of additional TS patients, will pave the way for a deeper understanding of the disease process.”

TS is a relatively common neurological disorder characterized by tics—involuntary, rapid, sudden movements or vocalizations that occur repeatedly in the same way. It affects as many as one out of 100 school age children. The tics begin in mid-childhood and peak at the start of adolescence. TS is not life threatening, but affected children commonly have other neuropsychiatric disorders including ADHD, obsessive-compulsive disorder or depression. State said TS patients swearing uncontrollably is actually uncommon, with only a small percentage of TS patients ever having this symptom.

For years, many researchers sought a single, abnormal gene for TS. Since none was found, it was concluded that multiple genes either cause or contribute to the disorder. While many researchers looked for genetic similarities among large groups of TS patients, State and his team took the opposite approach pioneered by co-author and Yale’s Chair of Genetics, Richard Lifton, M.D., of searching for unusual patients with TS. With help from the Tourette Syndrome Association, they found such a case in which a child had TS and carried a chromosomal abnormality.

Working with Yale neurobiologists and co-authors Nenad Sestan and Angeliki Louvi, the team used molecular methods to identify differences in that child’s DNA. In particular, they found one gene expressed in the brain near the chromosomal break point. They compared the gene to a wider TS population of 174 people. The team found an abnormal DNA sequence in one family and the identical, very rare change in the DNA sequence in two unrelated people. This second finding was in a non-coding region of the gene that does not directly make protein.

A lead author on the study, graduate student Kenneth Kwan made the key observation that this segment of the gene was likely to be involved in gene regulation through the interaction with small molecules called microRNAs. In a series of experiments, the research team found that this was indeed the case.

The study was supported in part by the National Institute of Neurological Disorders and Stroke and the National Center for Research Resources.

Other Yale authors who worked with researchers from several other institutions included Jesse F. Abelson, Brian J. O’Roak, Danielle Y. Baek, Althea A. Stillman, Thomas M. Morgan, Mladen-Roko Rasin, Nicole R. Davis, A. Gulhan Ercan-Sencicek, Daniel H. Guez, James F. Leckman, M.D., and Anita Farhi.

###

Citation: Science Vol. 310, No. 5746 (October 14, 2005)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Researchers At Yale Identify A Genetic Link To Tourette’s Syndrome." ScienceDaily. ScienceDaily, 13 October 2005. <www.sciencedaily.com/releases/2005/10/051013081828.htm>.
Yale University. (2005, October 13). Researchers At Yale Identify A Genetic Link To Tourette’s Syndrome. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2005/10/051013081828.htm
Yale University. "Researchers At Yale Identify A Genetic Link To Tourette’s Syndrome." ScienceDaily. www.sciencedaily.com/releases/2005/10/051013081828.htm (accessed August 29, 2014).

Share This




More Health & Medicine News

Friday, August 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins