Featured Research

from universities, journals, and other organizations

A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice

Date:
October 17, 2005
Source:
BioMed Central
Summary:
Mice with the mouse model of Alzheimer's disease show improvements in their condition when treated with a high-fat, low-carbohydrate diet. A report published today in the peer-reviewed, open access journal Nutrition and Metabolism, showed that a brain protein, amyloid-beta, which is an indicator of Alzheimer's disease, is reduced in mice on the so-called ketogenic diet.

Mice with the mouse model of Alzheimer's disease show improvements intheir condition when treated with a high-fat, low-carbohydrate diet. Areport published today in the peer-reviewed, open access journalNutrition and Metabolism, showed that a brain protein, amyloid-beta,which is an indicator of Alzheimer's disease, is reduced in mice on theso-called ketogenic diet.

The report, by Samuel Henderson, from Accera, Inc, Colorado andcolleagues from Belgium runs counter to previous studies suggesting anegative effect of fat on Alzheimer's disease.

"This work supports the premise that key aspects ofAlzheimer's disease can be altered by changes in metabolism. It alsohighlights the interaction of dietary components and how suchcomponents influence the metabolic state", write the authors.

The authors believe that insulin and the related hormone,insulin-related growth factor-1 (IGF-1), are the key players. "Insulinis often considered a storage hormone, since it promotes deposition offat but insulin may also work to encourage amyloid-beta production."

Richard Feinman, editor of the journal, explains the relationbetween nutrients: "You might say that fat is the bomb, and insulin(from carbohydrate) is the fuse. Most studies of the deleteriouseffects of fat have been done in the presence of high carbohydrate. Ifcarbs are high, dietary fat is not oxidized and is instead stored asbody fat." When carbohydrates are very low and fat is high, compoundscalled ketone bodies are generated (ketosis) and these compounds mayplay a role in the observed reduction in amyloid-beta. In associationwith a group from University of Washington led by Dr. Suzanne Craft,Henderson has previously shown cognitive improvement in patients withmild AD who were given a diet that raises ketone bodies.

In an accompanying editorial, Feinman says, "Although it istoo early to tell how the results will fit into the treatment of AD,the implication for diet in general is also important." The primacy ofinsulin as a control element is the basis of popular weight-loss dietsbased on carbohydrate restriction. Such regimens allow dieters toregulate fat and calorie intake by appetite alone as long ascarbohydrate intake remains minimal. Feinman points out, "Henderson'seffort is one of several recent studies that point the way tounderstanding metabolism beyond the issues surrounding simple fatreduction."

###

Article:
A ketogenic diet reduces amyloid beta 40 and 42 in amouse model of Alzheimer's disease
Ingrid Van der Auwera, Stefaan Wera, Fred Van Leuven, and Samuel T.Henderson
Nutrition & Metabolism, in press


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice." ScienceDaily. ScienceDaily, 17 October 2005. <www.sciencedaily.com/releases/2005/10/051017072307.htm>.
BioMed Central. (2005, October 17). A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2005/10/051017072307.htm
BioMed Central. "A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice." ScienceDaily. www.sciencedaily.com/releases/2005/10/051017072307.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins