Featured Research

from universities, journals, and other organizations

A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice

Date:
October 17, 2005
Source:
BioMed Central
Summary:
Mice with the mouse model of Alzheimer's disease show improvements in their condition when treated with a high-fat, low-carbohydrate diet. A report published today in the peer-reviewed, open access journal Nutrition and Metabolism, showed that a brain protein, amyloid-beta, which is an indicator of Alzheimer's disease, is reduced in mice on the so-called ketogenic diet.

Mice with the mouse model of Alzheimer's disease show improvements intheir condition when treated with a high-fat, low-carbohydrate diet. Areport published today in the peer-reviewed, open access journalNutrition and Metabolism, showed that a brain protein, amyloid-beta,which is an indicator of Alzheimer's disease, is reduced in mice on theso-called ketogenic diet.

The report, by Samuel Henderson, from Accera, Inc, Colorado andcolleagues from Belgium runs counter to previous studies suggesting anegative effect of fat on Alzheimer's disease.

"This work supports the premise that key aspects ofAlzheimer's disease can be altered by changes in metabolism. It alsohighlights the interaction of dietary components and how suchcomponents influence the metabolic state", write the authors.

The authors believe that insulin and the related hormone,insulin-related growth factor-1 (IGF-1), are the key players. "Insulinis often considered a storage hormone, since it promotes deposition offat but insulin may also work to encourage amyloid-beta production."

Richard Feinman, editor of the journal, explains the relationbetween nutrients: "You might say that fat is the bomb, and insulin(from carbohydrate) is the fuse. Most studies of the deleteriouseffects of fat have been done in the presence of high carbohydrate. Ifcarbs are high, dietary fat is not oxidized and is instead stored asbody fat." When carbohydrates are very low and fat is high, compoundscalled ketone bodies are generated (ketosis) and these compounds mayplay a role in the observed reduction in amyloid-beta. In associationwith a group from University of Washington led by Dr. Suzanne Craft,Henderson has previously shown cognitive improvement in patients withmild AD who were given a diet that raises ketone bodies.

In an accompanying editorial, Feinman says, "Although it istoo early to tell how the results will fit into the treatment of AD,the implication for diet in general is also important." The primacy ofinsulin as a control element is the basis of popular weight-loss dietsbased on carbohydrate restriction. Such regimens allow dieters toregulate fat and calorie intake by appetite alone as long ascarbohydrate intake remains minimal. Feinman points out, "Henderson'seffort is one of several recent studies that point the way tounderstanding metabolism beyond the issues surrounding simple fatreduction."

###

Article:
A ketogenic diet reduces amyloid beta 40 and 42 in amouse model of Alzheimer's disease
Ingrid Van der Auwera, Stefaan Wera, Fred Van Leuven, and Samuel T.Henderson
Nutrition & Metabolism, in press


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice." ScienceDaily. ScienceDaily, 17 October 2005. <www.sciencedaily.com/releases/2005/10/051017072307.htm>.
BioMed Central. (2005, October 17). A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2005/10/051017072307.htm
BioMed Central. "A High Fat, Low Carbohydrate Diet Improves Alzheimer's Disease In Mice." ScienceDaily. www.sciencedaily.com/releases/2005/10/051017072307.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins