Featured Research

from universities, journals, and other organizations

New University Of Toronto Strategy Will Boost Cord Blood Stem Cells

Date:
October 19, 2005
Source:
University of Toronto
Summary:
A team of bioengineers led by the University of Toronto has discovered a way to increase the yield of stem cells from umbilical cord blood, to an extent which could broaden therapeutic use of these cells.

A team of bioengineers led by the University of Toronto has discovereda way to increase the yield of stem cells from umbilical cord blood, toan extent which could broaden therapeutic use of these cells.

In a paper published in the October issue of ExperimentalHematology, researchers working in the University of Toronto's StemCell Bioengineering Laboratory have identified an important componentblocking the growth of stem cells. U of T scientists discovered stemcells in 1961, and for about two decades researchers around the worldhave been searching for a way to expand the number of stem cellsharvested from umbilical cord blood, which can be used instead of bonemarrow for transplantation into patients with blood cancers.

"It's been very hard to grow blood stem cells at all," says ProfessorPeter W. Zandstra of the University of Toronto's Institute ofBiomaterials and Biomedical Engineering, and head of the laboratory inwhich the research was conducted. "We've tried to understand how thosecells talk to each other, and by controlling that, trying to get theones we want to grow better."

In any culture, blood stem cells are very rare, Zandstraexplains: typically less than one in 100 cells. "If you want to growthat one cell among the other cells that are more aggressive, you haveto target that cell."

The research team developed a way to remove the non-stem cells --differentiated cells, or "lineage-positive" cells -- to create anenvironment that allows stem cells to grow better. "A mature[lineage-positive] cell expresses markers of differentiated lineages,and a stem cell is typically negative for these markers," Zandstrasays. "So we removed the lineage-positive cells. They secretemolecules, or cytokines, which inhibit growth of stem cells. So, byremoving them, we're making the environment better for stem cells."

Typically, the umbilical cord does not yield a large volume ofstem cells -- perhaps enough to treat a child, but rarely an adult. Thenew research findings may allow new cord-blood stem cells to bedeveloped in the laboratory -- enough to treat adult patients as wellas children. The major use of blood stem cells is for transplantationinto patients with leukemia and other blood-borne cancers.

From their studies in mice, the researchers know that new stemcells obtained through their expansion technology can engraft in bonemarrow and maintain special properties such as the ability to migratein the body.

The researchers have further refined their system by developinga "bioreactor" -- a vessel in which to grow the stem cells in a closedand controlled environment, away from environmental contaminants.

"The hope is that very soon, if the results are the same withthe bioreactor as they were with our experiments to date, we will moveto clinical trials," says Zandstra -- ideally within the next year.


Story Source:

The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University of Toronto. "New University Of Toronto Strategy Will Boost Cord Blood Stem Cells." ScienceDaily. ScienceDaily, 19 October 2005. <www.sciencedaily.com/releases/2005/10/051018072309.htm>.
University of Toronto. (2005, October 19). New University Of Toronto Strategy Will Boost Cord Blood Stem Cells. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2005/10/051018072309.htm
University of Toronto. "New University Of Toronto Strategy Will Boost Cord Blood Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2005/10/051018072309.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Reasons Why Teen Birth Rates Are At An All-Time Low

Reasons Why Teen Birth Rates Are At An All-Time Low

Newsy (Aug. 20, 2014) A CDC report says birth rates among teenagers have been declining for decades, reaching a new low in 2013. We look at several popular explanations. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins