Featured Research

from universities, journals, and other organizations

New University Of Toronto Strategy Will Boost Cord Blood Stem Cells

Date:
October 19, 2005
Source:
University of Toronto
Summary:
A team of bioengineers led by the University of Toronto has discovered a way to increase the yield of stem cells from umbilical cord blood, to an extent which could broaden therapeutic use of these cells.

A team of bioengineers led by the University of Toronto has discovereda way to increase the yield of stem cells from umbilical cord blood, toan extent which could broaden therapeutic use of these cells.

Related Articles


In a paper published in the October issue of ExperimentalHematology, researchers working in the University of Toronto's StemCell Bioengineering Laboratory have identified an important componentblocking the growth of stem cells. U of T scientists discovered stemcells in 1961, and for about two decades researchers around the worldhave been searching for a way to expand the number of stem cellsharvested from umbilical cord blood, which can be used instead of bonemarrow for transplantation into patients with blood cancers.

"It's been very hard to grow blood stem cells at all," says ProfessorPeter W. Zandstra of the University of Toronto's Institute ofBiomaterials and Biomedical Engineering, and head of the laboratory inwhich the research was conducted. "We've tried to understand how thosecells talk to each other, and by controlling that, trying to get theones we want to grow better."

In any culture, blood stem cells are very rare, Zandstraexplains: typically less than one in 100 cells. "If you want to growthat one cell among the other cells that are more aggressive, you haveto target that cell."

The research team developed a way to remove the non-stem cells --differentiated cells, or "lineage-positive" cells -- to create anenvironment that allows stem cells to grow better. "A mature[lineage-positive] cell expresses markers of differentiated lineages,and a stem cell is typically negative for these markers," Zandstrasays. "So we removed the lineage-positive cells. They secretemolecules, or cytokines, which inhibit growth of stem cells. So, byremoving them, we're making the environment better for stem cells."

Typically, the umbilical cord does not yield a large volume ofstem cells -- perhaps enough to treat a child, but rarely an adult. Thenew research findings may allow new cord-blood stem cells to bedeveloped in the laboratory -- enough to treat adult patients as wellas children. The major use of blood stem cells is for transplantationinto patients with leukemia and other blood-borne cancers.

From their studies in mice, the researchers know that new stemcells obtained through their expansion technology can engraft in bonemarrow and maintain special properties such as the ability to migratein the body.

The researchers have further refined their system by developinga "bioreactor" -- a vessel in which to grow the stem cells in a closedand controlled environment, away from environmental contaminants.

"The hope is that very soon, if the results are the same withthe bioreactor as they were with our experiments to date, we will moveto clinical trials," says Zandstra -- ideally within the next year.


Story Source:

The above story is based on materials provided by University of Toronto. Note: Materials may be edited for content and length.


Cite This Page:

University of Toronto. "New University Of Toronto Strategy Will Boost Cord Blood Stem Cells." ScienceDaily. ScienceDaily, 19 October 2005. <www.sciencedaily.com/releases/2005/10/051018072309.htm>.
University of Toronto. (2005, October 19). New University Of Toronto Strategy Will Boost Cord Blood Stem Cells. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2005/10/051018072309.htm
University of Toronto. "New University Of Toronto Strategy Will Boost Cord Blood Stem Cells." ScienceDaily. www.sciencedaily.com/releases/2005/10/051018072309.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins