Featured Research

from universities, journals, and other organizations

Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops

Date:
November 20, 2005
Source:
University of California, Davis - Health System
Summary:
Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer. But a small percentage of patients treated with these agents recover from their initial malignancy only to develop a second cancer, leukemia. Researchers at UC Davis Cancer Center have shed new light on this poorly understood process.

Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer. But a small percentage of patients treated with these agents recover from their initial malignancy only to develop a second cancer, leukemia.

Researchers at UC Davis Cancer Center have shed new light on this poorly understood process. In a study to be published in the Nov. 22 issue of the journal Leukemia, the researchers report that topoisomerase II inhibitors do not directly cause leukemia -- and suggest that it may be possible to prevent therapy-induced leukemia. (The study was posted online in the journal on Sept. 29.)

"There are two competing theories of how these therapy-induced leukemias arise," said Andrew Vaughan, a radiation biologist at UC Davis Cancer Center and senior author of the new study. "One is that the topoisomerase II inhibitor drugs, in combination with the topoisomerase II enzyme they target, induce random genetic changes that lead to leukemia onset. The other is that another, potentially correctable process is at work."

In the study, Vaughan and his colleagues at Loyola University and the Sacramento Veterans Administration Hospital linked what appears to be the earliest molecular event involved in the development of therapy-induced leukemia, the rearrangement of the MLL gene (a gene involved in leukemia), to factors that activate apoptosis, or programmed cell death.

"This rearrangement appears to be independent of the topoisomerase II enzyme," Vaughan said. "This suggests that another process, such as apoptosis itself, is involved."

Topoisomerase II inhibitors work by goading cancerous cells into apoptosis. Vaughan suggests that therapy-induced leukemia may occur when some cancer cells fail to complete apoptosis and instead survive in a mutated form that contains the leukemia-inducing MLL gene.

"The good news is that apoptosis is a well-understood and potentially correctable process," Vaughan said. "Through genetic or pharmacologic means, we may be able to manipulate the cells that survive chemotherapy to complete apoptosis and die -- averting the development of leukemia."

###

UC Davis Cancer Center is the only National Cancer Institute-designated cancer center serving the Central Valley and inland Northern California, a region the size of Pennsylvania. Its cancer research program brings together 180 scientists on three campuses: the UC Davis Medical Center campus in Sacramento, the main UC Davis campus in Davis, Calif., and Lawrence Livermore National Laboratory in Livermore, Calif.



Story Source:

The above story is based on materials provided by University of California, Davis - Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of California, Davis - Health System. "Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops." ScienceDaily. ScienceDaily, 20 November 2005. <www.sciencedaily.com/releases/2005/11/051120121423.htm>.
University of California, Davis - Health System. (2005, November 20). Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2005/11/051120121423.htm
University of California, Davis - Health System. "Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops." ScienceDaily. www.sciencedaily.com/releases/2005/11/051120121423.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins