Featured Research

from universities, journals, and other organizations

Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops

Date:
November 20, 2005
Source:
University of California, Davis - Health System
Summary:
Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer. But a small percentage of patients treated with these agents recover from their initial malignancy only to develop a second cancer, leukemia. Researchers at UC Davis Cancer Center have shed new light on this poorly understood process.

Topoisomerase II inhibitors are among the most successful chemotherapy drugs used to treat human cancer. But a small percentage of patients treated with these agents recover from their initial malignancy only to develop a second cancer, leukemia.

Researchers at UC Davis Cancer Center have shed new light on this poorly understood process. In a study to be published in the Nov. 22 issue of the journal Leukemia, the researchers report that topoisomerase II inhibitors do not directly cause leukemia -- and suggest that it may be possible to prevent therapy-induced leukemia. (The study was posted online in the journal on Sept. 29.)

"There are two competing theories of how these therapy-induced leukemias arise," said Andrew Vaughan, a radiation biologist at UC Davis Cancer Center and senior author of the new study. "One is that the topoisomerase II inhibitor drugs, in combination with the topoisomerase II enzyme they target, induce random genetic changes that lead to leukemia onset. The other is that another, potentially correctable process is at work."

In the study, Vaughan and his colleagues at Loyola University and the Sacramento Veterans Administration Hospital linked what appears to be the earliest molecular event involved in the development of therapy-induced leukemia, the rearrangement of the MLL gene (a gene involved in leukemia), to factors that activate apoptosis, or programmed cell death.

"This rearrangement appears to be independent of the topoisomerase II enzyme," Vaughan said. "This suggests that another process, such as apoptosis itself, is involved."

Topoisomerase II inhibitors work by goading cancerous cells into apoptosis. Vaughan suggests that therapy-induced leukemia may occur when some cancer cells fail to complete apoptosis and instead survive in a mutated form that contains the leukemia-inducing MLL gene.

"The good news is that apoptosis is a well-understood and potentially correctable process," Vaughan said. "Through genetic or pharmacologic means, we may be able to manipulate the cells that survive chemotherapy to complete apoptosis and die -- averting the development of leukemia."

###

UC Davis Cancer Center is the only National Cancer Institute-designated cancer center serving the Central Valley and inland Northern California, a region the size of Pennsylvania. Its cancer research program brings together 180 scientists on three campuses: the UC Davis Medical Center campus in Sacramento, the main UC Davis campus in Davis, Calif., and Lawrence Livermore National Laboratory in Livermore, Calif.



Story Source:

The above story is based on materials provided by University of California, Davis - Health System. Note: Materials may be edited for content and length.


Cite This Page:

University of California, Davis - Health System. "Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops." ScienceDaily. ScienceDaily, 20 November 2005. <www.sciencedaily.com/releases/2005/11/051120121423.htm>.
University of California, Davis - Health System. (2005, November 20). Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2005/11/051120121423.htm
University of California, Davis - Health System. "Researchers Shed New Light On How Chemotherapy-induced Leukemia Develops." ScienceDaily. www.sciencedaily.com/releases/2005/11/051120121423.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins