Featured Research

from universities, journals, and other organizations

Immunological Karma: T Cells Reactive To Old Flu Infections Make Unrelated Viral Infections Worse

Date:
November 28, 2005
Source:
Journal of Clinical Investigation
Summary:
Childhood infection with Epstein-Barr virus (EBV) is often asymptomatic, while in adolescents and adults it causes infectious mononucleosis (IM). University of Massachusetts Medical School scientists now show how, in a strange twist of immunological karma, T cells specific to a previously encountered virus (such as the flu) may come back to haunt you, by overzealously responding to a subsequent, unrelated viral infection like EBV, increasing the severity of the immune response and causing IM.

Childhood infection with Epstein-Barr virus (EBV) is often asymptomatic, while the same infection in adolescents and adults causes infectious mononucleosis (IM). Liisa Selin and colleagues from the University of Massachusetts Medical School now show how, in a strange twist of immunological karma, T cells specific to a previously encountered virus (such as the flu) may come back to haunt you, by overzealously responding to a subsequent, unrelated viral infection like EBV, thereby increasing the severity of the immune response and causing IM. Their results appear online on November 23 in advance of print publication in the December issue of the Journal of Clinical Investigation.

Related Articles


The authors found that, in patients with IM, memory CD8+ T cells specific to an epitope of the influenza virus encountered in a previous infection, also recognized and reacted to an epitope of the Epstein-Barr virus. These two epitopes, with only 33% similarity, stimulate different T cell activities, which in sum skew the immune response to EBV infection. Excessive lymphocyte proliferation contributes to the marked deviation in disease course and is symptomatic of IM.

Overall, this demonstration of cross-reactivity involving 2 immunodominant epitopes from 2 of the most common human viruses highlights the potential importance of cross-reactive T cells in human disease states.

###

Title: Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis

View the PDF of this article at: https://www.the-jci.org/artice.php?id=25078


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Immunological Karma: T Cells Reactive To Old Flu Infections Make Unrelated Viral Infections Worse." ScienceDaily. ScienceDaily, 28 November 2005. <www.sciencedaily.com/releases/2005/11/051125105751.htm>.
Journal of Clinical Investigation. (2005, November 28). Immunological Karma: T Cells Reactive To Old Flu Infections Make Unrelated Viral Infections Worse. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2005/11/051125105751.htm
Journal of Clinical Investigation. "Immunological Karma: T Cells Reactive To Old Flu Infections Make Unrelated Viral Infections Worse." ScienceDaily. www.sciencedaily.com/releases/2005/11/051125105751.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins