Featured Research

from universities, journals, and other organizations

Alzheimer's Disease Prevention May Be Easier Than Cure

Date:
December 10, 2005
Source:
Journal of Clinical Investigation
Summary:
Mayo Clinic Jacksonville researchers report evidence to suggest that prevention of amyloid beta (Abeta) deposition in the brain prior to Alzheimer's disease (AD) onset may be easier than curing established disease. An immunization strategy targeting Abeta42, or a second form of Abeta known as Abeta40, prevented onset of amyloid deposition in young, AD-prone mice. However, this strategy was not effective in altering Abeta deposition or clearance in mice with modest levels of preexisting Abeta deposits.

Mayo Clinic Jacksonville researchers report evidence to suggest that prevention of amyloid beta (Abeta) deposition in the brain prior to Alzheimer's disease (AD) onset may be easier than curing established disease. An immunization strategy targeting Abeta42, or a second form of Abeta known as Abeta40, prevented onset of amyloid deposition in young, AD-prone mice. However, this strategy was not effective in altering Abeta deposition or clearance in mice with modest levels of preexisting Abeta deposits.

Current hypotheses suggest that it is the accumulation over time of amyloid beta peptide 1–42 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease. The reduction of amyloid levels is therefore a major therapeutic objective. Todd Golde and colleagues from the Mayo Clinic Jacksonville report evidence to suggest that prevention of amyloid deposition may be easier than curing established Alzheimer's disease. Their results will appear online on December 8 in advance of print publication in the January 2006 issue of the Journal of Clinical Investigation.

The authors use transgenic mice genetically predisposed to accumulate amyloid deposits in their brain to show that an immunization strategy targeting Abeta42, or a second form of Abeta known as Abeta40, prevents the onset of amyloid deposition in these mice at a young age. In contrast, the anti-Abeta42 or anti-Abeta40 monoclonal antibodies were not effective in altering Abeta deposition in mice with modest levels of preexisting Abeta deposits, nor were they capable of clearing existing deposits.

The results suggest that it may be easier to prevent Abeta deposition than to alter Abeta once deposited. This method may be an effective strategy to prevent amyloid deposition prior to the onset of Alzheimer's disease, but may have limited benefit in a therapeutic setting where amyloid deposits are already well established within the brain.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Cite This Page:

Journal of Clinical Investigation. "Alzheimer's Disease Prevention May Be Easier Than Cure." ScienceDaily. ScienceDaily, 10 December 2005. <www.sciencedaily.com/releases/2005/12/051210120200.htm>.
Journal of Clinical Investigation. (2005, December 10). Alzheimer's Disease Prevention May Be Easier Than Cure. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2005/12/051210120200.htm
Journal of Clinical Investigation. "Alzheimer's Disease Prevention May Be Easier Than Cure." ScienceDaily. www.sciencedaily.com/releases/2005/12/051210120200.htm (accessed August 27, 2014).

Share This




More Mind & Brain News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com
Distracted Adults: ADHD?

Distracted Adults: ADHD?

Ivanhoe (Aug. 27, 2014) Most people don’t realize that ADHD isn’t just for kids. It can affect the work as well as personal lives of many adults, and often times they don’t even know they have it. Video provided by Ivanhoe
Powered by NewsLook.com
The Sight and Sounds of Autism

The Sight and Sounds of Autism

Ivanhoe (Aug. 27, 2014) A new study is explaining why for some people with autism what they see and what they hear is out of sync. Video provided by Ivanhoe
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins