Featured Research

from universities, journals, and other organizations

Langerhans Cells Regulate Immune Reactions In The Skin

Date:
December 20, 2005
Source:
Yale University
Summary:
Researchers at Yale School of Medicine have demonstrated that Langerhans cells in the skin, which had been thought to alert the immune system to pathogens, instead dampen the skin's reaction to infection and inflammation.

Researchers at Yale School of Medicine have demonstrated that Langerhans cells in the skin, which had been thought to alert the immune system to pathogens, instead dampen the skin's reaction to infection and inflammation.

Related Articles


This has the potential to significantly alter understanding of the mechanisms underlying many skin disorders such as psoriasis, lupus and skin cancer.

Dendritic cells are found throughout the body and are extremely efficient at alerting the immune system to the presence of pathogens and other foreign materials. Langerhans cells are dendritic cells in the skin. Skin is an important barrier to infection and it has been generally assumed that the Langerhans cells only serve to warn the immune system of skin pathogens.

According to the study, featured on the cover of the December 15 issue of Immunity, Langerhans cells are not required and, in fact, inhibit or modulate immune responses in the skin.

Daniel H. Kaplan, M.D., and Mark J. Shlomchik, M.D., used a technology called Bacterial Artificial Chromosome transgenics to develop a mouse model that lacks Langerhans cells in the skin from birth. They stimulated the skin of these mice to create hypersensitivity similar to a poison ivy reaction. They expected that mice without Langerhans cells would have less immune response in the skin.

"Unexpectedly, instead of a decreased immune response to contact hypersensitivity, we found a reproducible and significant increase," said first author Kaplan, assistant professor in the Department of Dermatology at Yale School of Medicine. "Langerhans cells are thus not required to generate immune responses in the skin and more profoundly, they actually regulate immune responses in the skin."

According to senior author Shlomchik, professor of laboratory medicine and immunobiology at Yale, "We now have a new view of these cells, not just as sentinels or stimulators of immune reactions as previously thought, but more as peacekeepers with the environment, which poses a constant challenge to skin. Most such challenges are not dangerous and do not warrant an immune response."

Langerhans cells may function generally to prevent excessive responses in the skin. "Failure of this mechanism could result in chronic inflammatory skin conditions like lupus and psoriasis, said Shlomchik. "This is the new theory we would now like to test."

The findings could also have future implications for skin transplantation, autoimmune diseases and the immune system's ability to prevent skin cancer.

###

Other authors on the study included Mathew C. Jenison, Sem Saeland and Warren D. Shlomchik.

The study was funded by the National Institutes of Health through the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and the Dermatology Foundation.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Langerhans Cells Regulate Immune Reactions In The Skin." ScienceDaily. ScienceDaily, 20 December 2005. <www.sciencedaily.com/releases/2005/12/051220000731.htm>.
Yale University. (2005, December 20). Langerhans Cells Regulate Immune Reactions In The Skin. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2005/12/051220000731.htm
Yale University. "Langerhans Cells Regulate Immune Reactions In The Skin." ScienceDaily. www.sciencedaily.com/releases/2005/12/051220000731.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins