Featured Research

from universities, journals, and other organizations

DNA Key To Predicting Prostate And Renal Cancer

Date:
January 31, 2006
Source:
Emory University Health Sciences Center
Summary:
In a study to be published in the February issue of "The Journal of Urology," researchers from Emory University School of Medicine have determined that inheritance of "mitochondrial haplogroup U" is associated with increased risk of prostate and renal cancers.

In a study to be published in the February issue of "The Journal of Urology," researchers from Emory University School of Medicine have determined that inheritance of "mitochondrial haplogroup U" is associated with increased risk of prostate and renal cancers.

Related Articles


John Petros, MD, associate professor of Urology at Emory, led the study with colleagues from Emory and the Mercer University School of Medicine. Statistics from the study show that 20 million people in the United States fall into the haplogroup U category and are therefore at an increased risk for prostate or renal cancer.

Mitochondrial DNA is passed down from the mother to her children, males and females. The genetic material of the mitochondria generates energy for cells and has long been known as a mediator for the natural process of apoptosis, or cell death. In this study, Dr. Petros and his colleagues researched the inheritance pattern of mitochondria in patients with cancer.

"The study found that inheritance of mitochondrial haplogroup U is associated with an approximately 2-fold increased risk of prostate cancer and 2.5-fold increased risk of renal cancer in white North American individuals," says Dr. Petros, who also serves as co-director of the Emory Winship Cancer Institute Prostate Cancer Program and director of Urologic Research at the Atlanta Veterans Administration Medical Center. "Mitochondrial haplogroup U is found in 9.35 percent of the white United States population, which means more than 20 million individuals are in this high risk group."

By comparing the mtDNA haplotype in patients with prostate and renal cancer to that in control groups, Petros has been able to determine an association between mitochondrial genotype and cancer risk. A haplotype is a set of closely linked alleles, which are genes or variations in the sequence of genetic information on a segment of DNA. "Haplo" comes from the Greek word for "single."

The study is relegated to white North American individuals in order to provide a specific set of parameters that can be used as a control.

"In this study, we document that the distributions of mitochondrial haplogroups in white North American patients with renal and prostate cancer are different from those in a regional control group of white North American individuals," says Dr. Petros.

The study also found that a consequence of having a single mitochondrial haplogroup that is predisposed to both prostate and renal cancers is an increased risk of both cancers. A review of statistics indicates and increased incidence of renal cancer in patients with prostate cancer and an increased rate of prostate cancer in patients with renal cancer.

Mitochondrial haplogroups have been associated with other diseases. For example, the H haplogroup has been linked to late onset Alzheimer's disease and the J haplogroup is connected to Liber's hereditary optic neuropathy.

"To our knowledge," says Dr. Petros, "no previous research has evaluated the association of inherited mitochondrial haplogroup with cancer."


Story Source:

The above story is based on materials provided by Emory University Health Sciences Center. Note: Materials may be edited for content and length.


Cite This Page:

Emory University Health Sciences Center. "DNA Key To Predicting Prostate And Renal Cancer." ScienceDaily. ScienceDaily, 31 January 2006. <www.sciencedaily.com/releases/2006/01/060131092759.htm>.
Emory University Health Sciences Center. (2006, January 31). DNA Key To Predicting Prostate And Renal Cancer. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2006/01/060131092759.htm
Emory University Health Sciences Center. "DNA Key To Predicting Prostate And Renal Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/01/060131092759.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins