Featured Research

from universities, journals, and other organizations

PDT Kills Drug-resistant Bacteria, Fungus In Lab Tests

Date:
March 10, 2006
Source:
University at Buffalo
Summary:
Photodynamic therapy may be an effective treatment for fungal infections and certain bacterial infections of the oral cavity, including some that are resistant to antibiotics, research from the University at Buffalo's School of Dental Medicine has shown.

Photodynamic therapy may be an effective treatment for fungal infections and certain bacterial infections of the oral cavity, including some that are resistant to antibiotics, research from the University at Buffalo's School of Dental Medicine has shown.

Researchers found that the bacteria S. mutans, as well as fungal organisms of the genus Candida, cultured from HIV patients, were highly susceptible to killing with minimal doses of PDT, both in laboratory dishes and on biofilms grown on denture material.

Results of the research were presented today (March 10, 2006) at the International Association of Dental Research meeting in Orlando, Fla.

"The results of the studies so far, while not completed, may have important implications in the treatment of oral infectious diseases currently confounding the medical and dental community," said Thomas S. Mang, Ph.D., associate professor of oral and maxillofacial surgery and senior author on the study.

"PDT may provide an adjunct to current antibiotic treatment or an alternative where antibiotics no longer are working. This may be vital for patients undergoing cancer therapy, HIV patients who demonstrate resistance to antibiotics and the elderly with persistent oral infections."

Photodynamic therapy is based on the propensity of certain types of cells or organisms to absorb light-sensitive drugs. This selective retention allows researchers to direct a laser beam into the organism, which activates the drug and kills the organism but does not damage surrounding tissue.

PDT has been shown to be effective against certain types of cancer, particularly Kaposi's sarcoma, cancer of the esophagus and breast cancer that has metastasized to the chest wall. The drug Photofrin® has been approved by the FDA as a sensitizer for PDT in the treatment of early and late stage endobronchial and esophageal cancers, as well as high-grade abnormal tissues associated with Barrett's esophagus, a peptic ulcer of the lower esophagus caused by the presence of cells that normally stay in the stomach lining.

In the current research, after adding the light-sensitive drug Photofrin® to the cultured samples and biofilm, the samples were exposed to various intensities of light.

Results showed that the photosensitizer accumulated in the samples within 15 minutes. Very low doses of light killed nearly all the S. mutans bacteria, reducing its concentration to less than 0.1 percent.

PDT also demonstrated significant killing of three types of Candida: C. albicans, which causes thrush, and C. glabrata and C. krusei, in samples harvested from immunocompromised (HIV) patients.

Additional researchers on the study from UB were Patricia Yen Bee Ng, biotechnology student; Maureen Donley, DDS., clinical associate professor of restorative dentistry, and Ernest Hausmann, D.M.D., Ph.D., professor emeritus of oral biology. Also, Alan Hutson, Ph.D., associate professor and chair of the Department of Biostatistics; Paul Bronson, research technician; Jean Wactowski-Wende, Ph.D., associate professor of social and preventive medicine, all from the UB School of Public Health and Health Professions.

Edward Rossomando, Ph.D., professor of biostructure function at the University of Connecticut, also contributed to the study.

The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York.


Story Source:

The above story is based on materials provided by University at Buffalo. Note: Materials may be edited for content and length.


Cite This Page:

University at Buffalo. "PDT Kills Drug-resistant Bacteria, Fungus In Lab Tests." ScienceDaily. ScienceDaily, 10 March 2006. <www.sciencedaily.com/releases/2006/03/060310101841.htm>.
University at Buffalo. (2006, March 10). PDT Kills Drug-resistant Bacteria, Fungus In Lab Tests. ScienceDaily. Retrieved August 28, 2014 from www.sciencedaily.com/releases/2006/03/060310101841.htm
University at Buffalo. "PDT Kills Drug-resistant Bacteria, Fungus In Lab Tests." ScienceDaily. www.sciencedaily.com/releases/2006/03/060310101841.htm (accessed August 28, 2014).

Share This




More Health & Medicine News

Thursday, August 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mini Pacemaker Has No Wires

Mini Pacemaker Has No Wires

Ivanhoe (Aug. 27, 2014) — Cardiac experts are testing a new experimental device designed to eliminate major surgery and still keep the heart on track. Video provided by Ivanhoe
Powered by NewsLook.com
After Cancer: Rebuilding Breasts With Fat

After Cancer: Rebuilding Breasts With Fat

Ivanhoe (Aug. 27, 2014) — More than 269 million women are diagnosed with breast cancer each year. Many of them will need surgery and radiation, but there’s a new simple way to reconstruct tissue using a patient’s own fat. Video provided by Ivanhoe
Powered by NewsLook.com
Blood Clots in Kids

Blood Clots in Kids

Ivanhoe (Aug. 27, 2014) — Every year, up to 200,000 Americans die from a blood clot that travels to their lungs. You’ve heard about clots in adults, but new research shows kids can get them too. Video provided by Ivanhoe
Powered by NewsLook.com
Radio Waves Knock out Knee Pain

Radio Waves Knock out Knee Pain

Ivanhoe (Aug. 27, 2014) — Doctors have used radio frequency ablation or RFA to reduce neck and back pain for years. But now, that same technique is providing longer-term relief for patients with severe knee pain. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins