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Horse Antibodies Against The Bird Flu Virus H5N1 Are Effective As Treatment In Mice

Date:
March 30, 2006
Source:
BioMed Central
Summary:
Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus. A study published in the open access journal Respiratory Research reveals that a dose of 100 ยตg of horse anti-serum effectively protects infected mice.

Antibodies against the bird flu virus H5N1, derived from horses, prevent mice infected with H5N1 from dying from the virus. A study published in the open access journal Respiratory Research (http://respiratory-research.com) reveals that a dose of 100 ตg of horse anti-serum effectively protects infected mice. These results suggest that anti-H5N1 antibodies developed in horses could potentially be used to prevent death from H5N1 influenza, or as early treatment for the disease, in humans.

Jiahai Lu from Sun Yat-Sen University in Guangzhou, China and colleagues from other institutions in China infected dog kidney cells in vitro with a lethal dose of H5N1 and simultaneously exposed the cells to horse antibodies against H5N1. Lu et al.'s results show that horse antibodies to H5N1 protected cells against H5N1 in vitro – the cells simultaneously infected with H5N1 and exposed to horse antibodies did not die.

Lu et al. then injected horse antibodies into 40 mice that had been infected with a lethal dose of H5N1 24 hours earlier. The authors also injected horse serum without H5N1 antibodies into a group of mice that acted as controls.

The authors found that 50ตg of antibody protected 70% of the mice against death by H5N1 and 100 ตg of antibody protected 100% of the mice. The mice in the control group died nine hours after receiving the normal horse serum.


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The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


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BioMed Central. "Horse Antibodies Against The Bird Flu Virus H5N1 Are Effective As Treatment In Mice." ScienceDaily. ScienceDaily, 30 March 2006. <www.sciencedaily.com/releases/2006/03/060330084126.htm>.
BioMed Central. (2006, March 30). Horse Antibodies Against The Bird Flu Virus H5N1 Are Effective As Treatment In Mice. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2006/03/060330084126.htm
BioMed Central. "Horse Antibodies Against The Bird Flu Virus H5N1 Are Effective As Treatment In Mice." ScienceDaily. www.sciencedaily.com/releases/2006/03/060330084126.htm (accessed September 20, 2014).

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