Featured Research

from universities, journals, and other organizations

Variants In Three Estrogen-related Genes Linked To Parkinson's Disease In Women

Date:
April 14, 2006
Source:
Mayo Clinic
Summary:
Mayo Clinic researchers have discovered a possible connection between increased risk for Parkinson's disease and variants in three genes that control estrogen production and activity in the body.

Mayo Clinic researchers have discovered a possible connection between increased risk for Parkinson's disease and variants in three genes that control estrogen production and activity in the body.

The findings will be presented Tuesday at the American Academy of Neurology meeting in San Diego.

"We and other investigators have found evidence that estrogen helps protect women from developing Parkinson's," says Walter Rocca, M.D., M.P.H., Mayo Clinic neurologist and epidemiologist, and lead study investigator. "So, a gene variant that would decrease estrogen production or activity would put those women at greater risk for the disease."

The study associated variants in the following three genes with development of Parkinson's: estrogen receptor 1 gene (ESR1); estrogen receptor 2 gene (ESR2); and PR domain-containing protein 2 gene (PRDM2).

"The gene variants are not a defect or a problem in and of themselves -- they are part of human differences, simply differences across people, like being slim, short or blue-eyed," says Dr. Rocca. "These differences make one subgroup of the population more susceptible to a disease like Parkinson's. However, sometimes the genetic variant is a weak risk factor, and the disease only manifests if another risk factor is present, such as a particular diet, physical exercise, taking certain medications or a medical event."

The study was conducted using a database from a previous study of the entire human genome for genes linked to Parkinson's. For the new study, the Mayo Clinic investigators examined several genes for variants in 172 women who had Parkinson's and 229 women who did not have the disease.

Dr. Rocca explains that some genetic variants the study pinpointed for association with Parkinson's are quite common, affecting 10 to 20 percent of the female population. As women are not routinely tested for these gene variations, however, those affected would be unaware, he says.

"If the findings of this study are replicated and confirmed, the hope is to use these variants to predict the risk of disease using a simple blood test," says Dr. Rocca. He explains that the test would be particularly useful for women and their physicians before deciding to conduct an elective ovariectomy, surgical removal of the ovaries, because a combination of estrogen-reducing factors could amplify a woman's risk for Parkinson's.

Other members of the Mayo Clinic research team included: Brandon Grossardt; Mariza de Andrade, Ph.D.; James Bower, M.D.; and Demetrius Maraganore, M.D. The study was financially supported by grants from the National Institutes of Health.



Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Variants In Three Estrogen-related Genes Linked To Parkinson's Disease In Women." ScienceDaily. ScienceDaily, 14 April 2006. <www.sciencedaily.com/releases/2006/04/060414002812.htm>.
Mayo Clinic. (2006, April 14). Variants In Three Estrogen-related Genes Linked To Parkinson's Disease In Women. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2006/04/060414002812.htm
Mayo Clinic. "Variants In Three Estrogen-related Genes Linked To Parkinson's Disease In Women." ScienceDaily. www.sciencedaily.com/releases/2006/04/060414002812.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins