Featured Research

from universities, journals, and other organizations

New Predictive Model To Assess Individual's Risk Of Prostate Cancer

Date:
April 19, 2006
Source:
Journal of the National Cancer Institute
Summary:
Researchers have developed a model to predict prostate cancer for men who undergo a prostate biopsy. The details of the risk calculator appear in the April 18 issue of the Journal of the National Cancer Institute.

Researchers have developed a model to predict prostate cancer for men who undergo a prostate biopsy. The details of the risk calculator appear in the April 18 issue of the Journal of the National Cancer Institute.

Fifty percent of men in the United States undergo regular screening for prostate cancer, using a test that measures levels of prostate-specific antigen (PSA), a protein secreted by the prostate gland. However, recent research looking at PSA levels after a prostate biopsy has revealed that PSA level is not a very accurate predictor of prostate cancer risk. Prostate cancer can occur when PSA levels are "normal." Other variables, such as family history, age, race, and digital rectal examination (DRE) results also play a role in assessing prostate cancer risk.

To better assess prostate cancer risk, Ian M. Thompson, M.D., of the University of Texas Health Science Center at San Antonio, and colleagues analyzed information on 5519 men aged 55 or older from the placebo group of the Prostate Cancer Prevention Trial (PCPT). Men in the PCPT were followed for 7 years, receiving regular PSA screening and DREs annually. If tests were abnormal, men underwent a prostate biopsy to check for prostate cancer. Men also underwent biopsies at the end of the study if they had not undergone a biopsy during the study. The researchers used various statistical tests to analyze biopsy results, family history of prostate cancer, race, age, rectal examination results, and previous biopsy history.

The authors used the equations generated by their analysis to develop a risk calculator that can be used to assess an individual's risk of prostate cancer. The risk calculator is available online and can be used to calculate risk of prostate cancer and high-grade disease for men aged 50 years or and older who have no previous history of prostate cancer and who have had recent PSA screening and DRE tests.

The authors write, "This risk calculator model uses variables that go beyond only PSA level to help patients and physicians decide whether a prostate biopsy should be performed. We anticipate that the area of cancer risk modeling -- including the incorporation of new risk variables and the understanding of patient decision-making -- will have a measurable clinical impact over the next few years."

In an accompanying editorial, H. Ballentine Carter, M.D., of the Johns Hopkins School of Medicine in Baltimore, brings up concerns about over treatment of prostate cancer if the model were to pick up the non-lethal varieties of prostate cancer. He writes, "In the absence of accurate markers of life-threatening disease, I do not believe that physicians should endorse any approach to predicting the risk of prostate cancer that is likely to increase the diagnosis of biologically unimportant cancers. Once we have the ability to assess multiple risk factors (e.g., PSA or other new markers) in populations for which the long-term outcomes are known, approaches like the one described by Thompson, et al. will help identify those men who will benefit from active treatment."

Article: Thompson IM, Ankerst DP, Chen C, Goodman PJ, Tangen CM, Lucia MS, et al. Assessing Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial. J Natl Cancer Inst 2006; 98:529-534.

Editorial: Carter HB. Assessing Risk: Does This Patient Have Prostate Cancer? J Natl Cancer Inst 2006; 98:506-507.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "New Predictive Model To Assess Individual's Risk Of Prostate Cancer." ScienceDaily. ScienceDaily, 19 April 2006. <www.sciencedaily.com/releases/2006/04/060419075546.htm>.
Journal of the National Cancer Institute. (2006, April 19). New Predictive Model To Assess Individual's Risk Of Prostate Cancer. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2006/04/060419075546.htm
Journal of the National Cancer Institute. "New Predictive Model To Assess Individual's Risk Of Prostate Cancer." ScienceDaily. www.sciencedaily.com/releases/2006/04/060419075546.htm (accessed September 1, 2014).

Share This




More Health & Medicine News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Liberia Continues Fight Against Ebola

Liberia Continues Fight Against Ebola

AFP (Aug. 30, 2014) Authorities in Liberia try to stem the spread of the Ebola epidemic by raising awareness and setting up sanitation units for people to wash their hands. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

California Passes 'yes-Means-Yes' Campus Sexual Assault Bill

Reuters - US Online Video (Aug. 30, 2014) California lawmakers pass a bill requiring universities to adopt "affirmative consent" language in their definitions of consensual sex, part of a nationwide drive to curb sexual assault on campuses. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
New Drug Could Reduce Cardiovascular Deaths

New Drug Could Reduce Cardiovascular Deaths

Newsy (Aug. 30, 2014) The new drug from Novartis could reduce cardiovascular deaths by 20 percent compared to other similar drugs. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins