Featured Research

from universities, journals, and other organizations

Chemotherapy Gel May Fight Breast Cancer And Reduce Breast Deformity

Date:
April 26, 2006
Source:
University of Pittsburgh Medical Center
Summary:
University of Pittsburgh researchers have developed a polymer-based therapy for breast cancer that could serve as an artificial tissue filler after surgery and a clinically effective therapy. The treatment could be applicable to women with breast deformities from breast cancer surgery followed by radiation therapy. The findings, based on mouse studies, will be presented on Tuesday, April 25 at the World Congress on Tissue Engineering and Regenerative Medicine at the Westin Convention Center in Pittsburgh.

Women who undergo surgery for breast cancer followed by radiation therapy often experience breast deformities that can only be corrected through reconstructive surgery. Researchers at the McGowan Institute for Regenerative Medicine, in collaboration with bioengineers at Carnegie Mellon University, have developed a polymer-based therapy for breast cancer that could serve as an artificial tissue filler after surgery and a clinically effective therapy. Their findings, based on studies with mice, will be presented at 10:15 a.m., Tuesday, April 25 at the World Congress on Tissue Engineering and Regenerative Medicine, April 24 to 27, at the Westin Convention Center in Pittsburgh.

Related Articles


"Although radiation therapy is the standard treatment for breast cancer following surgery, it is expensive, time consuming and increases the cosmetic deformity caused by surgery," said Howard D. Edington, M.D., associate professor of surgery and surgical oncology at the University of Pittsburgh and faculty member at McGowan. "We sought to develop a possible alternative to radiation therapy that would not only release chemotherapy slowly to kill the cancerous cells left behind after surgery but that also would fill in the dimples and sometimes quite significant indentations that are common after breast surgery and radiation."

To test their idea, the researchers encapsulated a common breast cancer chemotherapy drug, doxorubicin, in microspheres, or beads, and then mixed them with a gelatin made of a polymer substance. Mice with breast cancer tumors were treated by inserting the gel under the skin next to the mammary gland. The researchers found that they could successfully control the delivery of chemotherapy over a period of 30 days and that the tumors were completely eradicated compared to a control group of mice that were implanted with the gel insert without chemotherapy.

"Through further research and testing, our goal is to develop this into a clinical treatment for women undergoing breast cancer surgery," said Dr. Edington who also is chief of surgery at Magee-Womens Hospital. "This treatment may help decrease the occurrences of breast deformity. With more studies under our belt, we believe this approach could eventually represent an alternative to breast radiation after surgery."

According to Dr. Edington, clinical trials on women with breast cancer will follow additional laboratory studies. A paper detailing these results will be published in the Journal of Biomedical Materials Research.

Co-authors of the study include Alicia J. DeFail, Kacey Marra, Ph.D., Frank Cartieri, Nithya Rajendran and Wen-Chi C. Lee, all with University of Pittsburgh or Carnegie Mellon University. The study is funded by a grant from the United States Department of Defense.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "Chemotherapy Gel May Fight Breast Cancer And Reduce Breast Deformity." ScienceDaily. ScienceDaily, 26 April 2006. <www.sciencedaily.com/releases/2006/04/060426081809.htm>.
University of Pittsburgh Medical Center. (2006, April 26). Chemotherapy Gel May Fight Breast Cancer And Reduce Breast Deformity. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2006/04/060426081809.htm
University of Pittsburgh Medical Center. "Chemotherapy Gel May Fight Breast Cancer And Reduce Breast Deformity." ScienceDaily. www.sciencedaily.com/releases/2006/04/060426081809.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins