Featured Research

from universities, journals, and other organizations

Onset Of Psychosis May Be Delayed By Medication

Date:
May 1, 2006
Source:
Yale University
Summary:
Administration of an anti-psychotic medication may minimize or delay the onset of psychosis in young people who clearly seem to be developing early signs of schizophrenia.

New Haven, Conn.--For young people who clearly seem to be developing early signs of schizophrenia, treatment with the antipsychotic drug olanzapine appears to lower or delay the rate of conversion to full-blown psychosis, according to an article by a Yale School of Medicine researcher in the May issue of The American Journal of Psychiatry.

The findings are preliminary since 60 patients began the study and 17 completed it. Despite the long recruitment period and multiple study sites, participation was limited by the low incidence of pre-psychotic, or "prodromal," symptoms in the general population.

Schizophrenia affects about one percent of the population, or three million people, and is one of the most disabling medical disorders.

"Delay of the onset of the most severe symptoms of schizophrenia appears to have occurred because of the early recognition and treatment of these persons," said Robert Freedman, M.D., editor-in-chief of The American Journal of Psychiatry. "This enabled them to be better connected with treatment and to cope better with this devastating illness."

The study, "The Prevention Through Risk Identification, Management, and Education (PRIME)," was conducted in two U.S. cities and two Canadian cities during 1998-2003. Senior author of the study was Thomas McGlashan, M.D., professor in the Department of Psychiatry at Yale.

The participants were mostly adolescents. The individuals or their parents sought treatment because the adolescents had symptoms resembling those of psychosis, but less severe. Symptoms included occasional periods of persecutory thoughts, abnormal sensory experiences such as hearing unusual sounds, and brief periods of incoherent thoughts, among other symptoms. Earlier studies suggest that many of these individuals would eventually develop the full symptoms of schizophrenia--persistent paranoia, auditory hallucinations and disability.

The participants were randomly assigned for one year to olanzapine, a drug often used to treat schizophrenia, or placebo, and then were observed for an additional year after treatment was stopped.

During the year of treatment the olanzapine group had greater improvement in prodromal symptoms with conversion to full psychosis in 16 percent of the olanzapine patients and 38 percent of the placebo patients. In following year, after the treatment was discontinued, the rates of conversion to psychosis did not differ and symptoms increased for the patients previously treated with olanzapine.

Research into the early detection and treatment of schizophrenia has become important to determine whether psychosis and/or some of its disabilities can be prevented. Recent investigations have examined whether a long duration of untreated psychosis leads to a poorer outcome after treatment begins. Clinical trials to determine whether schizophrenia can be delayed or prevented are now possible due to improvements in antipsychotic medications and in identification of high-risk individuals.

Weight gain is a frequent side effect of olanzapine, although it does not cause body tremors as did the first generation of antipsychotic medications. The patients in the PRIME study who took olanzapine gained an average of 19 pounds. Increases in glucose and cholesterol levels are also common in patients taking antipsychotic medications, but the patients in this study did not develop these symptoms.

Eli Lilly Company and the National Institute of Mental Health funded the study.

Citation: The American Journal of Psychiatry 163: 790-799 (May 1, 2006)


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Cite This Page:

Yale University. "Onset Of Psychosis May Be Delayed By Medication." ScienceDaily. ScienceDaily, 1 May 2006. <www.sciencedaily.com/releases/2006/05/060501101509.htm>.
Yale University. (2006, May 1). Onset Of Psychosis May Be Delayed By Medication. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2006/05/060501101509.htm
Yale University. "Onset Of Psychosis May Be Delayed By Medication." ScienceDaily. www.sciencedaily.com/releases/2006/05/060501101509.htm (accessed July 31, 2014).

Share This




More Mind & Brain News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dieting At A Young Age Might Lead To Harmful Health Habits

Dieting At A Young Age Might Lead To Harmful Health Habits

Newsy (July 30, 2014) Researchers say women who diet at a young age are at greater risk of developing harmful health habits, including eating disorders and alcohol abuse. Video provided by Newsy
Powered by NewsLook.com
It's Not Just Facebook: OKCupid Experiments With Users Too

It's Not Just Facebook: OKCupid Experiments With Users Too

Newsy (July 29, 2014) If you've been looking for love online, there's a chance somebody has been looking at how you're looking. Video provided by Newsy
Powered by NewsLook.com
How Your Face Can Leave A Good Or Bad First Impression

How Your Face Can Leave A Good Or Bad First Impression

Newsy (July 29, 2014) Researchers have found certain facial features can make us seem more attractive or trustworthy. Video provided by Newsy
Powered by NewsLook.com
Losing Sleep Leaves You Vulnerable To 'False Memories'

Losing Sleep Leaves You Vulnerable To 'False Memories'

Newsy (July 27, 2014) A new study shows sleep deprivation can make it harder for people to remember specific details of an event. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins