Featured Research

from universities, journals, and other organizations

Study Reveals Vioxx Related Heart Attacks Can Occur Within The First Two Weeks Of Use

Date:
May 3, 2006
Source:
McGill University
Summary:
A quarter of patients who suffered a heart attack while taking Vioxx did so within the first two weeks of taking the drug, a new study published by MUHC investigators reveals. The research, scheduled for early online publication in the Canadian Medical Association Journal (CMAJ) today, demonstrates that cardiovascular risks from taking Vioxx may occur much earlier than previously believed.

MONTREAL, 1 May 2006--A quarter of patients who suffered a heart attack while taking Vioxx did so within the first two weeks of taking the drug, a new study published by MUHC investigators reveals. The research, scheduled for early online publication in the Canadian Medical Association Journal (CMAJ) today, demonstrates that cardiovascular risks from taking Vioxx may occur much earlier than previously believed. "Our previous study on COX-2 inhibitors, which included Vioxx and Celebrex, evaluated whether there was an increased risk of heart attack while taking these medications; the answer was yes for Vioxx," says Linda Levesque, a doctoral student in the Department of Epidemiology and Biostatistics at McGill University, researcher at the MUHC in Montreal and lead author of the new study. "Our current study assessed the pattern of cardiovascular risk in Québec seniors over a three year period, in order to establish the timing of this risk."

Levesque, in collaboration with Dr. James Brophy , a cardiologist/epidemiologist and Director of the Technology Assessment Unit (TAU) at the MUHC and Associate Professor of Medicine at McGill University, and Bin Zhang, also a doctoral student in the Department of Epidemiology and Biostatistics, discovered that the risk of heart attack from Vioxx is much more acute than previously recognized. "A quarter of individuals in our study who suffered an acute myocardial infarction did so within two weeks of their first Vioxx prescription," says Levesque.

"The additional cardiovascular risk from Vioxx actually decreased with longer duration of use, suggesting that the period of highest susceptibility for most people taking Vioxx may occur earlier than previously believed," noted Levesque. The study also documents that cardiovascular risk returns to normal within one month of stopping the drug.

Vioxx was voluntarily withdrawn from the market on September 30, 2004 after a study showed it doubled patients' risk of heart attacks and strokes after 18 months of use. This MUHC study is the first to specifically address the question of the timing of cardiovascular risk associated with COX-2 inhibitors.

"This study adds important new information on how the COX-2 inhibitors like Vioxx affect the heart," said Dr. Peter Liu, Scientific Director of the CIHR Institute of Circulatory and Respiratory Health. "Physicians must carefully assess the risk versus benefit, and help the patient to watch for any new symptoms during the start of these medications. We are delighted that this research from the McGill University Health Centre can help us further to better the health of Canadians."

This study was funded by the Canadian Institutes for Health Research (CIHR).

The Research Institute of the McGill University Health Centre (RI MUHC) is a world-renowned biomedical and health-care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, a university health center affiliated with the Faculty of Medicine at McGill University. The institute supports over 500 researchers, nearly 1000 graduate and post-doctoral students and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge. For further details visit: www.muhc.ca/research.

The McGill University Health Centre (MUHC) is a comprehensive academic health institution with an international reputation for excellence in clinical programs, research and teaching. The MUHC is a merger of five teaching hospitals affiliated with the Faculty of Medicine at McGill University -- the Montreal Children's, Montreal General, Royal Victoria, and Montreal Neurological Hospitals, as well as the Montreal Chest Institute. Building on the tradition of medical leadership of the founding hospitals, the goal of the MUHC is to provide patient care based on the most advanced knowledge in the health care field, and to contribute to the development of new knowledge.


Story Source:

The above story is based on materials provided by McGill University. Note: Materials may be edited for content and length.


Cite This Page:

McGill University. "Study Reveals Vioxx Related Heart Attacks Can Occur Within The First Two Weeks Of Use." ScienceDaily. ScienceDaily, 3 May 2006. <www.sciencedaily.com/releases/2006/05/060502172943.htm>.
McGill University. (2006, May 3). Study Reveals Vioxx Related Heart Attacks Can Occur Within The First Two Weeks Of Use. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2006/05/060502172943.htm
McGill University. "Study Reveals Vioxx Related Heart Attacks Can Occur Within The First Two Weeks Of Use." ScienceDaily. www.sciencedaily.com/releases/2006/05/060502172943.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Condemned Man's US Execution Takes Nearly Two Hours

Condemned Man's US Execution Takes Nearly Two Hours

AFP (July 24, 2014) — America's death penalty debate raged Thursday after it took nearly two hours for Arizona to execute a prisoner who lost a Supreme Court battle challenging the experimental lethal drug cocktail. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
China's Ageing Millions Look Forward to Bleak Future

China's Ageing Millions Look Forward to Bleak Future

AFP (July 24, 2014) — China's elderly population is expanding so quickly that children struggle to look after them, pushing them to do something unexpected in Chinese society- move their parents into a nursing home. Duration: 02:07 Video provided by AFP
Powered by NewsLook.com
Hundreds in Virginia Turn out for a Free Clinic to Manage Health

Hundreds in Virginia Turn out for a Free Clinic to Manage Health

AFP (July 24, 2014) — America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th - prompting hundreds in Virginia to turn out for a free clinic run by “Remote Area Medical”. Duration 02:40 Video provided by AFP
Powered by NewsLook.com
Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins