Featured Research

from universities, journals, and other organizations

New Technology Addresses Female Fertility Preservation

Date:
July 10, 2006
Source:
Northwestern University
Summary:
A team of scientists from Northwestern University has developed a three-dimensional culture system that encapsulates follicles and allows immature eggs to grow and mature in vitro. This novel technology has already led to the live birth of healthy mice from in vitro grown follicles.

Women at risk for infertility, such as those needing cancer treatment, can freeze mature, fertilized eggs, but the process can take up to six weeks and for some this delay of treatment is not an option.

Related Articles


Immature follicles (the female egg and surrounding somatic cells) can be preserved at any time but are difficult to mature when removed from their normal environment.

A team of scientists from Northwestern University has developed a three-dimensional culture system that encapsulates follicles and allows immature eggs to grow and mature in vitro. (A follicle is a small spherical group of specialized support cells surrounding each egg.) This novel technology has already led to the live birth of healthy mice from in vitro grown follicles.

The results are published online this month by the journal Tissue Engineering.

The study shows that follicles grown individually in a three-dimensional biomaterial called alginate maintain normal connections between follicle and egg, resulting in the development of eggs, which can be fertilized and ultimately lead to healthy embryos and the birth of live mice. Previously developed methods of growing follicles or eggs outside of the body do not provide the three-dimensional support to maintain the follicle structure in which the egg must grow.

“While the research is in its early stages, this work has implications for the preservation of fertility for women and girls with cancer,” said Teresa K. Woodruff, Professor of Neurobiology and Physiology who led the study together with Lonnie D. Shea, Associate Professor of Chemical and Biological Engineering. “This system establishes a core technology for human egg banks for preservation of fertility.”

The technology mimics the ovary and its environment. Follicles (each follicle has one egg) from mice were grown in vitro until fully matured by providing the follicles and eggs with the necessary hormones for development while maintaining their normal architecture. The eggs were then used for in vitro fertilization. The fertilized eggs were implanted into a foster mother that was of a different strain than the donor egg and sperm, resulting in babies with a different coat color, proving that the births were the result of the cultured embyros. Both male and female offspring were fertile.

In addition to Woodruff and Shea, other authors on the paper are Min Xu and Pamela K. Kreeger, both from Northwestern.

The research was supported by the National Institute of Child Health and Human Development through the Northwestern University Specialized Centers Program in Reproductive Research.


Story Source:

The above story is based on materials provided by Northwestern University. Note: Materials may be edited for content and length.


Cite This Page:

Northwestern University. "New Technology Addresses Female Fertility Preservation." ScienceDaily. ScienceDaily, 10 July 2006. <www.sciencedaily.com/releases/2006/07/060710084202.htm>.
Northwestern University. (2006, July 10). New Technology Addresses Female Fertility Preservation. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2006/07/060710084202.htm
Northwestern University. "New Technology Addresses Female Fertility Preservation." ScienceDaily. www.sciencedaily.com/releases/2006/07/060710084202.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins