Featured Research

from universities, journals, and other organizations

Reducing Side Effects Of Painkillers

Date:
September 19, 2006
Source:
Cardiff University
Summary:
Cardiff University researchers have increased the understanding of why some painkillers increase the risk of heart attack and stroke. Working with colleagues at Vanderbilt University in Tennessee, they have discovered a link with levels of nitric oxide in the blood.

Cardiff University researchers have increased the understanding of why some painkillers increase the risk of heart attack and stroke.

The most commonly prescribed medications for treating conditions such as arthritis are non-steroidal anti-inflammatory drugs (NSAIDs) which include, for example, ibuprofen. These drugs reduce pain, fever and inflammation but also carry a greater risk of cardiovascular side effects in some patients. However, the factors that cause such adverse effects were unknown.

Now a team in Cardiff University's School of Medicine, working with colleagues at Vanderbilt University in Tennessee, have discovered a link with levels of nitric oxide in the blood.

Blood vessels use nitric oxide to signal the surrounding smooth muscle to relax, dilating the artery and increasing blood flow. Patients with cardiovascular disease and arthritis have lower blood vessel nitric oxide levels.

Dr Valerie O'Donnell, of the School of Medicine's Department of Medical Biochemistry and Immunology at Cardiff University said: "We have found that reducing nitric oxide levels in some rodents makes them more likely to suffer cardiovascular side effects from NSAIDs, such as increased blood pressure. Although this is a small study, it will be important now to look at whether this happens in humans. It may mean that monitoring nitric oxide, or replacing it in certain individuals may help decrease the risk of side effects."


Story Source:

The above story is based on materials provided by Cardiff University. Note: Materials may be edited for content and length.


Cite This Page:

Cardiff University. "Reducing Side Effects Of Painkillers." ScienceDaily. ScienceDaily, 19 September 2006. <www.sciencedaily.com/releases/2006/09/060915203455.htm>.
Cardiff University. (2006, September 19). Reducing Side Effects Of Painkillers. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2006/09/060915203455.htm
Cardiff University. "Reducing Side Effects Of Painkillers." ScienceDaily. www.sciencedaily.com/releases/2006/09/060915203455.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins