Featured Research

from universities, journals, and other organizations

Rheumatoid Arthritis And Sex Differences

Date:
September 29, 2006
Source:
John Wiley & Sons, Inc.
Summary:
To thoroughly investigate sex differences in RA, a team of researchers turned to families with a history of the disease among both their female and male members. The results indicate that male sex exerts a significant influence on underlying RA mechanisms, particularly the production of anti-CCP antibodies.

To thoroughly investigate sex differences in RA, a team of researchers turned to families with a history of the disease among both their female and male members. The results indicate that male sex exerts a significant influence on underlying RA mechanisms, particularly the production of anti-CCP an

Related Articles


Rheumatoid arthritis (RA), a chronic autoimmune disease marked by tissue inflammation and joint destruction, has a well established predisposition for women.

Among the adults it strikes--currently about two million in the United States--the female to male ratio is three to one. RA incidence also varies by age within each sex. Among women, disease occurrence increases from the age of menarche and peaks around menopause; RA is rare in men under age 45. These trends have prompted numerous studies into the role of hormones in the development of RA. However, sex differences in specific risk factors, disease expression, and response to treatment have remained largely unexplored.

To thoroughly investigate sex differences in RA, a team of researchers affiliated with the University of California turned to families with a history of the disease among both their female and male members. The results, presented in the October 2006 issue of Arthritis & Rheumatism, indicate that male sex exerts a significant influence on underlying RA mechanisms, particularly the production of anti-CCP antibodies.

The study focused on 1,004 affected members of 467 Caucasian families within which two or more siblings met the American College of Rheumatology (ACR) criteria for RA. All families were recruited from the North American Rheumatoid Arthritis Consortium, a resource for gene mapping studies. Each RA patient was interviewed to collect relevant personal details, including age at onset of RA symptoms, age at RA diagnosis, medication history, and smoking history. Each patient was examined for joint tenderness, completed a Health Assessment Questionnaire (HAQ), and underwent radiographs of the hands and wrists to evaluate bone erosions. Each patient was also genotyped for markers in the HLA region and tested for two hallmarks of the disease: rheumatoid factor (RF) and antibodies to cyclic citrullinated peptides (CCP).

Comparisons of demographic and clinical features between men and women with RA revealed several differences. Although male patients had significantly later onset of RA, they showed more signs of erosive disease, were more likely to test positive for RF factor and anti-CCP antibodies, and had higher titers or concentrations of these autoantibodies than female patients. Men were also significantly more likely to have a history of smoking. Female patients had significantly higher HAQ scores, which translates into poorer function, and were more likely to have other autoimmune diseases, particularly autoimmune thyroid disease, than male patients.

The most notable finding involved women who shared RA with a brother. Among them, the presence and production of anti-CCP antibodies was significantly higher than among female patients without an affected male sibling. In fact, the findings suggest that the sisters of men with RA are approximately twice as likely to be anti-CCP autoantibody positive and to have higher anti-CCP titers as the general population of women with RA. What's more, the researchers concluded that increased production of anti-CCP antibodies appears to be a feature of families with affected males rather than an inherent characteristic of male RA patients.

"The significantly increased autoantibody titers among male patients and among families with affected male siblings is particularly striking and represents a novel observation," stresses the study's leading author, Lindsey A. Criswell, M.D., M.PH. "Anti-CCP antibody production is a very strong predictor of RA, particularly erosive RA."

This comprehensive study of sex differences offers important implications for the early detection and effective treatment of RA--for both sexes. Additional studies of families with affected males may identify additional genetic or other risk factors for this complex autoimmune disease.

Article: "Influence of Male Sex on Disease Phenotype in Familial Rheumatoid Arthritis," Damini Jawaheer, Raymond F. Lum, Peter K. Gregersen, and Lindsey A. Criswell, Arthritis & Rheumatism, October 2006; (DOI: 10.1002/art.22120).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Rheumatoid Arthritis And Sex Differences." ScienceDaily. ScienceDaily, 29 September 2006. <www.sciencedaily.com/releases/2006/09/060928095421.htm>.
John Wiley & Sons, Inc.. (2006, September 29). Rheumatoid Arthritis And Sex Differences. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2006/09/060928095421.htm
John Wiley & Sons, Inc.. "Rheumatoid Arthritis And Sex Differences." ScienceDaily. www.sciencedaily.com/releases/2006/09/060928095421.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins