Featured Research

from universities, journals, and other organizations

Three-dimensional, Miniature Endoscope Opens New Diagnostic Possibilities

Date:
October 19, 2006
Source:
Massachusetts General Hospital
Summary:
Massachusetts General Hospital researchers have developed a new type of miniature endoscope that produces three-dimensional, high-definition images, which may greatly expand the application of minimally invasive diagnostic and therapeutic procedures.

The spectral encoded miniature endoscope uses micro optics and a single optical fiber to project various colors of light onto different portions of the subject. The light reflected back into the endoscope is measured and analyzed to produce a three-dimensional image. This illustration shows a time exposure of white light transmitted through the miniature endoscope, superimposed on a three-dimensional rendering of mouse metastatic ovarian tumor nodules obtained with this new technique.
Credit: Wellman Center for Photomedicine, Massachusetts General Hospital

Massachusetts General Hospital (MGH) researchers have developed a new type of miniature endoscope that produces three-dimensional, high-definition images, which may greatly expand the application of minimally invasive diagnostic and therapeutic procedures. In the October 19 issue of Nature, the team from the Wellman Center for Photomedicine at MGH describes their prototype device and a demonstration of its use in a mouse model.

Related Articles


"This new ultraminiature endoscope is the first to allow three-dimensional imaging of areas inside the body," says Guillermo Tearney, MD, PhD, of the MGH Wellman Center, the report's senior author. "Its ability to go places that other imaging tools cannot reach opens new possibilities for medical diagnosis and eventually treatment."

Standard miniature endoscopic devices -- which give physicians access to hard-to-reach internal organs and structures -- utilize bundles of optical fibers to supply light to and transmit images from the areas of interest. Larger endoscopes that use image sensors to produce high-quality, two-dimensional images can be a centimeter or more in diameter. Existing miniature endoscopes using smaller fiber bundles may be more flexible but have difficulty producing high-quality images.

The new device developed at MGH-Wellman uses a technology called spectrally encoded endoscopy (SEE). Multicolored light from a single optical fiber -- introduced through a probe about the size of a human hair -- is broken into its component colors and projected onto tissue, with each color illuminating a different part of the tissue surface. The light reflected back is recorded, and the intensity of the various colors decoded by a spectrometer, which analyzes the wavelengths of light. Another device called an interferometer, which calculates structural information based on the interaction between two waves of light, provides the data required to create three-dimensional images.

To demonstrate the device's application in a live animal, the researchers used the system to image metastatic ovarian tumors on the abdominal wall of a mouse. The SEE probe was passed into the abdominal cavity through a fine-gauge needle. The resulting three-dimensional image showed several raised areas of tumor nodules, the presence of which was confirmed by histologic analysis of the tissue.

"The most important feature of this new endoscope is the ability to obtain three-dimensional images, something we don't believe is offered by any commercially available miniature endoscope system," says Dvir Yelin, PhD, first author of the Nature paper. "While the image resolution we achieved in this demonstration is similar to existing small-diameter endoscopes, with further optimization of the optics it is possible to obtain images with 10 times the number of pixels provided by other miniature endoscopes."

"This new technology will offer physicians and surgeons the capability to bring many more procedures into outpatient settings, reduce anesthesia requirements and minimize tissue damage," Tearney adds. "The device's size and flexibility should allow safer navigation through such delicate structures as the salivary ducts, the fallopian tubes and the pancreatic duct. Fetal and pediatric procedures may also benefit from this tool. Eventually, SEE could give rise to new procedures that permit diagnosis and microsurgery in previously inaccessible areas of the body."

Tearney is an associate professor of Pathology at Harvard Medical School. He and his colleagues are working on adapting the SEE device for human studies in the near future. Additional co-authors of the Nature report are Imran Rizvi, Matthew White, MD, Jason Motz, PhD, Tayyaba Hasan, PhD, and Brett Bouma, PhD -- all of the Wellman Center. The research was supported by grants from the Center for the Integration of Medicine and Innovative Technology, the National Science Foundation and the Whitaker Foundation.


Story Source:

The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.


Cite This Page:

Massachusetts General Hospital. "Three-dimensional, Miniature Endoscope Opens New Diagnostic Possibilities." ScienceDaily. ScienceDaily, 19 October 2006. <www.sciencedaily.com/releases/2006/10/061018150820.htm>.
Massachusetts General Hospital. (2006, October 19). Three-dimensional, Miniature Endoscope Opens New Diagnostic Possibilities. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2006/10/061018150820.htm
Massachusetts General Hospital. "Three-dimensional, Miniature Endoscope Opens New Diagnostic Possibilities." ScienceDaily. www.sciencedaily.com/releases/2006/10/061018150820.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Matter & Energy News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Building Google Into Cars

Building Google Into Cars

Reuters - Business Video Online (Dec. 19, 2014) Google's next Android version could become the standard that'll power your vehicle's entertainment and navigation features, Reuters has learned. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
AP Review: Nikon D750 and GoPro Hero 4

AP Review: Nikon D750 and GoPro Hero 4

AP (Dec. 19, 2014) What to buy an experienced photographer or video shooter? There is some strong gear on the market from Nikon and GoPro. The AP's Ron Harris takes a closer look. (Dec. 19) Video provided by AP
Powered by NewsLook.com
Obama: Better Ways to Create Jobs Than Keystone Pipeline

Obama: Better Ways to Create Jobs Than Keystone Pipeline

AFP (Dec. 19, 2014) US President Barack Obama says that construction of the Keystone pipeline would have 'very little impact' on US gas prices and believes there are 'more direct ways' to create construction jobs. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins