Featured Research

from universities, journals, and other organizations

New Antibody-Based Treatment May Facilitate Mother-to-Child Antiretroviral Immunity

Date:
October 18, 2006
Source:
American Society For Microbiology
Summary:
A new study suggests that mothers may be able to transfer antiretroviral immunity during gestation and while breastfeeding when receiving a new antibody-based treatment say researchers from France. They report their findings in the October 2006 issue of the Journal of Virology.

A new study suggests that mothers may be able to transfer antiretroviral immunity during gestation and while breastfeeding when receiving a new antibody-based treatment say researchers from France. They report their findings in the October 2006 issue of the Journal of Virology.

Monoclonal antibodies (MAb) are now the largest class of engineered proteins in the medical field, with 19 already approved by the FDA for human use. With more than 400 others involved in human clinical trials researchers are looking to apply this new therapeutic format to cancer and immune defects, as well as infectious diseases.

The FrCas (E) retrovirus is a neurodegenerative disease that led to death within 1 to 2 months when mice were infected at 5 to 6 days old. In the study researchers investigated whether the antibodies from MAb 667-treated mothers with strong anti-FrCas (E) immune responses could affect the immune systems of their FrCAS (E) infected pups following placental and/or breastfeeding transfer. Results showed reduction in the viral load and protective antiviral response from breastfeeding alone as well as placental transfer. Researchers also found that placental transfer protected animals infected neonatally and initiated a neutralizing anti-FrCas (E) response.

"Our data support the concept that passive immunotherapies during late gestation and/or breastfeeding might help retrovirally infected neonates prime their own protective immune responses, in addition to exerting an immediate antiviral effect," say the researchers.

(L. Gros, M. Pelegrin, M. Plays, M. Piechaczyk. 2006. Efficient mother-to-child transfer of antiretroviral immunity in the context of preclinical monoclonal antibody-based immunotherapy. Journal of Virology, 80.20: 10191-10200.)


Story Source:

The above story is based on materials provided by American Society For Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

American Society For Microbiology. "New Antibody-Based Treatment May Facilitate Mother-to-Child Antiretroviral Immunity." ScienceDaily. ScienceDaily, 18 October 2006. <www.sciencedaily.com/releases/2006/10/061018151227.htm>.
American Society For Microbiology. (2006, October 18). New Antibody-Based Treatment May Facilitate Mother-to-Child Antiretroviral Immunity. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2006/10/061018151227.htm
American Society For Microbiology. "New Antibody-Based Treatment May Facilitate Mother-to-Child Antiretroviral Immunity." ScienceDaily. www.sciencedaily.com/releases/2006/10/061018151227.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins