Featured Research

from universities, journals, and other organizations

Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation

Date:
November 9, 2006
Source:
University of Pittsburgh Medical Center
Summary:
Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation.

Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb, according to an animal study presented today by University of Pittsburgh researchers at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Philadelphia.

"Ionizing radiation can be extremely damaging to cells, tissues, organs and organ systems," said Joel S. Greenberger, M.D., professor and chairman department of radiation oncology, University of Pittsburgh School of Medicine. "In previous studies, we demonstrated that gene therapy can be both swallowed in pill form and inhaled through a nebulizer prior to radiation exposure to protect healthy tissues from damage. In this study, we found that the same therapy administered intravenously also offers protection during exposure to whole-body irradiation." Dr. Greenberger added that intravenous administration could potentially offer wide-reaching protection to the public in the event of a terrorist attack since experts believe a significant number of the population would die within 30 days of receiving a large dose of radiation to the entire body.

In the study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation. The researchers found that in a control group of mice that received an initial 9 Gy dose of radiation there was 80 percent survival at 30 days compared to 93.3 percent survival during the same length of time for an experimental group of mice that were injected with MnSOD-PL prior to irradiation. As the level of radiation exposure was increased, survival rates in the mice injected with MnSOD-PL prior to exposure increased significantly. For example, at 9.5 Gy, mice in the control group had a survival rate of 53 percent, while mice in the experimental group had a survival rate of 87 percent. Following irradiation to 9.75 Gy, only 12.5 percent of the mice in the control group survived, while 75 percent of the MnSOD-PL group survived.

"Intravenous administration of gene therapy appears to prevent the damaging effects of radiation, suggesting it is a viable delivery method," said Dr. Greenberger. "Future clinical studies will tell us whether this therapy can protect people from the deadly effects of radiation."

The study's co-authors include Michael W. Epperly, Ph.D., and Yunyun Niu, Ph.D., both with the department of radiation oncology at the University of Pittsburgh School of Medicine. The study was funded by a $10 million grant from the National Institute of Allergy and Infectious Diseases (NIAID) to the University of Pittsburgh School of Medicine in 2005 to create a Center for Medical Countermeasures Against Radiation.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation." ScienceDaily. ScienceDaily, 9 November 2006. <www.sciencedaily.com/releases/2006/11/061108154931.htm>.
University of Pittsburgh Medical Center. (2006, November 9). Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2006/11/061108154931.htm
University of Pittsburgh Medical Center. "Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation." ScienceDaily. www.sciencedaily.com/releases/2006/11/061108154931.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins