Featured Research

from universities, journals, and other organizations

Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation

Date:
November 9, 2006
Source:
University of Pittsburgh Medical Center
Summary:
Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb. In the University of Pittsburgh study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation.

Gene therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb, according to an animal study presented today by University of Pittsburgh researchers at the 48th Annual Meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO) in Philadelphia.

"Ionizing radiation can be extremely damaging to cells, tissues, organs and organ systems," said Joel S. Greenberger, M.D., professor and chairman department of radiation oncology, University of Pittsburgh School of Medicine. "In previous studies, we demonstrated that gene therapy can be both swallowed in pill form and inhaled through a nebulizer prior to radiation exposure to protect healthy tissues from damage. In this study, we found that the same therapy administered intravenously also offers protection during exposure to whole-body irradiation." Dr. Greenberger added that intravenous administration could potentially offer wide-reaching protection to the public in the event of a terrorist attack since experts believe a significant number of the population would die within 30 days of receiving a large dose of radiation to the entire body.

In the study, mice were used to test the protective effects of manganese superoxide dismutase plasmid liposome (MnSOD-PL) gene therapy on the bone marrow during whole-body irradiation. The researchers found that in a control group of mice that received an initial 9 Gy dose of radiation there was 80 percent survival at 30 days compared to 93.3 percent survival during the same length of time for an experimental group of mice that were injected with MnSOD-PL prior to irradiation. As the level of radiation exposure was increased, survival rates in the mice injected with MnSOD-PL prior to exposure increased significantly. For example, at 9.5 Gy, mice in the control group had a survival rate of 53 percent, while mice in the experimental group had a survival rate of 87 percent. Following irradiation to 9.75 Gy, only 12.5 percent of the mice in the control group survived, while 75 percent of the MnSOD-PL group survived.

"Intravenous administration of gene therapy appears to prevent the damaging effects of radiation, suggesting it is a viable delivery method," said Dr. Greenberger. "Future clinical studies will tell us whether this therapy can protect people from the deadly effects of radiation."

The study's co-authors include Michael W. Epperly, Ph.D., and Yunyun Niu, Ph.D., both with the department of radiation oncology at the University of Pittsburgh School of Medicine. The study was funded by a $10 million grant from the National Institute of Allergy and Infectious Diseases (NIAID) to the University of Pittsburgh School of Medicine in 2005 to create a Center for Medical Countermeasures Against Radiation.


Story Source:

The above story is based on materials provided by University of Pittsburgh Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University of Pittsburgh Medical Center. "Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation." ScienceDaily. ScienceDaily, 9 November 2006. <www.sciencedaily.com/releases/2006/11/061108154931.htm>.
University of Pittsburgh Medical Center. (2006, November 9). Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2006/11/061108154931.htm
University of Pittsburgh Medical Center. "Intravenous Gene Therapy Protects Normal Tissue Of Mice During Whole-body Radiation." ScienceDaily. www.sciencedaily.com/releases/2006/11/061108154931.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins