Featured Research

from universities, journals, and other organizations

Sex Differences And Rheumatoid Arthritis

Date:
December 30, 2006
Source:
John Wiley & Sons, Inc.
Summary:
A humanized mouse model may be valuable for not only studying sex differences in RA, but also for understanding why women are particularly vulnerable to autoimmunity and for developing future therapeutic strategies.

Characterized by chronic synovial tissue inflammation, increasing erosions of cartilage and bone, and eventual destruction of joints, rheumatoid arthritis (RA) is a complex and confounding autoimmune disease. It is associated with a variety of genetic and environmental factors and known to strike women about three times as frequently as men. A major obstacle to investigating this clear sex bias has been the lack of a laboratory rat or mouse that mimics human RA. Until now.

Related Articles


Researchers at the Mayo Clinic have produced a new breed of transgenic mice with autoimmune responses similar to human RA patients and increased incidence of the disease in females. Featured in the January 2007 issue of Arthritis & Rheumatism, this humanized mouse model may be valuable for not only studying sex differences in RA, but also for understanding why women are particularly vulnerable to autoimmunity and for developing future therapeutic strategies.

For this novel experiment, mice were genetically modified with a well-established RA susceptibility, the allele HLA-DRB1*0401. This gene variant is linked to anti-cyclic citrullinated peptide (anti-CCP) autoantibodies, which precede the onset of RA. Collagen-induced arthritis (CIA) in the mice was initiated by injection of type II collagen. These transgenic mice were then tested for incidence and severity of arthritic symptoms, as well as assessed for vulnerability to the disease by sex.

Of the transgenic mice that developed arthritis, all produced rheumatoid factors and anti-CCP autoantibodies strikingly similar to humans. These included auto antibodies to type II collagen (CII), increased expression of class II molecules T cells, and production of proinflammatory cytokines. In addition, female mice developed arthritis at a higher rate than the male mice, by a ratio greater than 3 to 1, and exhibited all the disease hallmarks at higher levels.

Commenting on this study's implications for further understanding and future treatment of RA, Maurizio Cutolo, M.D., a researcher with the Department of Rheumatology, the University of Genoa, Italy, considers its potential to shed light on the role of estrogen and androgen in the disease. "Sex hormone balance is a crucial factor in the regulation of immune and inflammatory responses," Dr. Cutolo notes. "Modulation of this balance should represent part of advanced biologic treatments for RA. Sharing the sex hormone effects of the human disease, the new humanized mouse may provide a better model with which to study the pathogenesis and treatment of arthritis."

Article: "New Humanized HLA-DR4-Transgenic Mice That Mimic the Sex Bias of Rheumatoid Arthritis," Veena Taneja, Marshall Behrens, Ashutosh Mangalam, Marie M. Griffiths, Harvinder S. Luthra, and Chella S. David, Arthritis & Rheumatism, January 2007; (DOI: 10.1002/art.22213).

Editorial: "Sex and Rheumatoid Arthritis: Mouse Model Versus Human Disease," Maurizio Cutolo, Arthritis & Rheumatism, January 2007; (DOI: 10.1002/art.22322).


Story Source:

The above story is based on materials provided by John Wiley & Sons, Inc.. Note: Materials may be edited for content and length.


Cite This Page:

John Wiley & Sons, Inc.. "Sex Differences And Rheumatoid Arthritis." ScienceDaily. ScienceDaily, 30 December 2006. <www.sciencedaily.com/releases/2006/12/061228131515.htm>.
John Wiley & Sons, Inc.. (2006, December 30). Sex Differences And Rheumatoid Arthritis. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2006/12/061228131515.htm
John Wiley & Sons, Inc.. "Sex Differences And Rheumatoid Arthritis." ScienceDaily. www.sciencedaily.com/releases/2006/12/061228131515.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins