Featured Research

from universities, journals, and other organizations

Benefits Of Testosterone Treatment Unknown, Research Shows

Date:
January 10, 2007
Source:
Mayo Clinic
Summary:
Little research exists demonstrating that testosterone is both safe from the cardiovascular standpoint and effective to treat sexual dysfunction, reveal Mayo Clinic researchers in two new studies.

Little research exists demonstrating that testosterone is both safe from the cardiovascular standpoint and effective to treat sexual dysfunction, reveal Mayo Clinic researchers in two new studies.

In articles published in the January issue of Mayo Clinic Proceedings, Mayo Clinic physicians call for large studies to help clinicians and patients make informed decisions about when testosterone should be prescribed.

"One of the initial surprises is how limited the research evidence is regarding whether testosterone is an effective treatment for sexual dysfunction while being safe from the cardiovascular disease standpoint," says Victor M. Montori, M.D., MSc, lead researcher for Mayo Clinic's Knowledge and Encounter Research Unit, and an author of the two studies in Mayo Clinic Proceedings. "There is no way for physicians to be certain when prescribing testosterone that, on average, it's doing more good than harm."

Both studies involved review and meta-analysis of randomized trials to assess the effect of testosterone on sexual dysfunction and cardiovascular events. Authors determined that no strong evidence exists showing testosterone doesn't cause cardiovascular harm and results regarding its impact on sexual dysfunction are inconsistent.

In 2004, the Endocrine Society established a task force to generate evidence-based guidelines about the use of testosterone in treating men. Dr. Montori says Mayo researchers joined the effort in order to help the Endocrine Society provide recommendations based on up-to-date research.

"We found that the evidence for whether men are better off being treated with testosterone is much weaker than the evidence for giving estrogen to post-menopausal women was before the big estrogen trials came out," Dr. Montori says.

Despite the weak evidence supporting testosterone's efficacy, drug companies have successfully driven its sale, Dr. Montori says. Currently, physicians may be prescribing testosterone to otherwise healthy men who report poor quality of life, limited sex drive and fatigue and may have somewhat low testosterone levels.

These clinicians and their patients will be "thoroughly shocked" to discover the limited evidence supporting the drug's effectiveness in treating sexual dysfunction and the limited data supporting its cardiovascular safety, Dr. Montori says. "Researchers should conduct trials measuring the outcomes of testosterone treatment that are important to patients in order to avoid repeating the estrogen disaster," he says.

In an editorial accompanying the testosterone studies, physicians from the University of Rome agree that there isn't enough known about testosterone treatment. Andrea Isidori, M.D., Ph.D., and Andrea Lenzi, M.D., Ph.D., say researchers only have begun to explore the potential effects of testosterone, and also call for rigorous trials.

Along with Dr. Montori, authors for the Mayo Clinic Proceedings article on testosterone use in men with sexual dysfunction are Enrique Bolona, M.D.; Maria Uraga, M.D.; Rudy Haddad, M.D.; Michael Tracz, M.D.; Kostandinos Sideras, M.D.; Cassie Kennedy, M.D.; Sean Caples, D.O.; and Patricia Erwin, all of Mayo Clinic.

Authors for the article on testosterone and cardiovascular risk in men are, along with Dr. Montori; Rudy Haddad, M.D.; Cassie Kennedy, M.D.; Sean Caples, D.O.; Michal Tracz, M.D.; Enrique Bolona, M.D.; Kostandinos Sideras, M.D.; Maria Uraga, M.D.; and Patricia Erwin, all of Mayo Clinic.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Benefits Of Testosterone Treatment Unknown, Research Shows." ScienceDaily. ScienceDaily, 10 January 2007. <www.sciencedaily.com/releases/2007/01/070109172205.htm>.
Mayo Clinic. (2007, January 10). Benefits Of Testosterone Treatment Unknown, Research Shows. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2007/01/070109172205.htm
Mayo Clinic. "Benefits Of Testosterone Treatment Unknown, Research Shows." ScienceDaily. www.sciencedaily.com/releases/2007/01/070109172205.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins